Srivastava K C
Prostaglandins Leukot Med. 1985 May;18(2):227-33. doi: 10.1016/0262-1746(85)90022-8.
Effects of ascorbic acid at physiologically achieved concentrations were examined on the metabolism of exogenous dihomo-gamma -linolenic acid and arachidonic acid (AA) in washed human platelets, and of AA in rat aortic rings. In the presence of ascorbic acid an increased formation of PGF1 alpha, PGE1 and PGE2 was observed in platelets. Also this vitamin induced an increased production of prostacyclin (measured as its stable metabolite 6-keto-PGF1 alpha) from exogenously provided substrate in aortic rings. In addition, from endogenous stores of AA in aortic rings ascorbic acid induced an increased generation of prostacyclin as revealed by inhibition of ADP-induced platelet aggregation.
研究了生理浓度的抗坏血酸对洗涤后的人血小板中外源性二高-γ-亚麻酸和花生四烯酸（AA）代谢的影响，以及对大鼠主动脉环中AA代谢的影响。在抗坏血酸存在的情况下，观察到血小板中PGF1α、PGE1和PGE2的生成增加。这种维生素还能使主动脉环中由外源性提供的底物生成更多的前列环素（以其稳定代谢产物6-酮-PGF1α来衡量）。此外，通过抑制ADP诱导的血小板聚集发现，抗坏血酸能使主动脉环中AA的内源性储存产生更多的前列环素。
