体外老化对培养的大鼠血管平滑肌细胞中前列腺素合成的影响。

Effect of in vitro aging on prostaglandin synthesis in cultured rat vascular smooth muscle cells.

作者信息

Takeuchi K, Abe K, Sato M, Yasujima M, Hagino T, Fang S, Yoshinaga K

机构信息

2nd Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Agents Actions Suppl. 1987;22:49-54. doi: 10.1007/978-3-0348-9299-5_5.

DOI:10.1007/978-3-0348-9299-5_5

PMID:3324719

Abstract

Cultured rat vascular smooth muscle cells from mesenteric artery produced prostaglandin (PG)E2, PGF2 alpha, PGI2 and thromboxane (TX)A2 in response to arachidonic acid, calcium ionophore A23187, vasopressin and angiotensin II. PGI2 was the major product among these PGs. PG synthesis in these cells decreased with in vitro aging, but the distribution pattern of PG synthesis did not change up to the passage level 56. Therefore, it is suggested that imbalance among PGs may not be directly implicated in vascular diseases in aging.

摘要

来自肠系膜动脉的培养大鼠血管平滑肌细胞在受到花生四烯酸、钙离子载体A23187、血管加压素和血管紧张素II刺激时会产生前列腺素（PG）E2、PGF2α、前列环素（PGI2）和血栓素（TX）A2。PGI2是这些前列腺素中的主要产物。这些细胞中的PG合成随着体外培养时间的延长而减少，但在传代至第56代时PG合成的分布模式并未改变。因此，提示PG之间的失衡可能与衰老过程中的血管疾病无直接关联。