Schmunk G A, Lefer A M
Res Commun Chem Pathol Pharmacol. 1982 Feb;35(2):179-87.
Four calcium channel blockers, verapamil, nifedipine, nisoldipine and nimodipine were studied in terms of their ability to inhibit platelet aggregation in cat platelet rich plasma by optical aggregometry. Only verapamil and nisoldipine significantly inhibited aggregation in cat platelets to ADP (2 microM). None of the calcium channel blockers exerted marked inhibition of aggregation induced by 1mM arachidonic acid. However, verapamil produced a moderate but significant inhibition of aggregation to arachidonic acid. Increasing the calcium ion concentration could reverse this inhibition. Thus, there are significant differences in the anti-aggregatory activity of calcium channel blockers in cat platelet rich plasma.
通过光学聚集测定法，对四种钙通道阻滞剂维拉帕米、硝苯地平、尼索地平及尼莫地平抑制猫富含血小板血浆中血小板聚集的能力进行了研究。仅维拉帕米和尼索地平能显著抑制猫血小板对二磷酸腺苷（2微摩尔）的聚集。没有一种钙通道阻滞剂对1毫摩尔花生四烯酸诱导的聚集产生明显抑制作用。然而，维拉帕米对花生四烯酸诱导的聚集产生了中度但显著的抑制作用。增加钙离子浓度可逆转这种抑制作用。因此，钙通道阻滞剂在猫富含血小板血浆中的抗聚集活性存在显著差异。
