维拉帕米和地尔硫䓬对猫和兔富血小板血浆中聚集反应的影响。

Influence of verapamil and diltiazem on aggregatory responses in cat and rabbit platelet rich plasma.

作者信息

Lippton H L, Horwitz P M, McNamara D B, Landry A Z, Kadowitz P J

出版信息

Prostaglandins Leukot Med. 1984 Oct;16(1):121-30. doi: 10.1016/0262-1746(84)90092-1.

Abstract

The effects of verapamil and diltiazem, calcium channel blockers, on aggregatory responses to ADP, arachidonic acid (AA), U46619, a thromboxane A2 mimic, and prostaglandin H2 (PGH2) were investigated in cat and rabbit platelet rich plasma. Results of the present study demonstrate that verapamil and diltiazem inhibit cat or rabbit platelet aggregation induced by ADP, AA, U46619, and PGH2. Furthermore, the present experiments provide the first reported data showing the inhibitory actions of calcium channel blockers on aggregatory responses to PGH2, the pivotal endoperoxide intermediate of arachidonic acid metabolism. Since verapamil and diltiazem at similar concentrations inhibited aggregatory responses to a similar degree in platelet rich plasma from cat or rabbit, the present data indicate that the influence of verapamil and diltiazem on platelet aggregation may be independent of species studied as well as nonspecific in nature.

摘要

在猫和兔富含血小板的血浆中，研究了钙通道阻滞剂维拉帕米和地尔硫䓬对血小板对二磷酸腺苷（ADP）、花生四烯酸（AA）、血栓素A2类似物U46619以及前列腺素H2（PGH2）的聚集反应的影响。本研究结果表明，维拉帕米和地尔硫䓬可抑制由ADP、AA、U46619和PGH2诱导的猫或兔血小板聚集。此外，本实验提供了首个报告数据，显示钙通道阻滞剂对PGH2聚集反应的抑制作用，PGH2是花生四烯酸代谢的关键内过氧化物中间体。由于维拉帕米和地尔硫䓬在相似浓度下对猫或兔富含血小板血浆中的聚集反应抑制程度相似，因此本数据表明，维拉帕米和地尔硫䓬对血小板聚集的影响可能与所研究的物种无关，且本质上是非特异性的。