Van Camp B, Reynaert P, Van Beers D
Rev Infect Dis. 1982 Jan-Feb;4(1):173-8.
A congenital toxoplasmosis infection was diagnosed in a newborn child with severe oculo-central nervous system involvement. Antibodies to toxoplasma became detectable in the mother's serum during pregnancy, and at delivery both mother and child had high titers of IgG toxoplasma antibody. A normal protein profile was found in the serum of the mother, but transient monoclonal gammopathy (IgG1- lambda ) was found in the child. A specific antiidiotype serum raised against this monoclonal immunoglobulin failed to react with the serum of the mother and with other sera positive for toxoplasma antibody. The toxoplasma antibody in the serum of the newborn child was restricted to IgG-lambda, but no evidence was found that the monoclonal fraction was responsible for the antibody activity.
一名患有严重眼-中枢神经系统受累的新生儿被诊断为先天性弓形虫感染。母亲血清中在孕期可检测到弓形虫抗体，分娩时母亲和孩子的弓形虫IgG抗体滴度均很高。母亲血清中蛋白质谱正常，但孩子血清中发现了短暂性单克隆丙种球蛋白病（IgG1-λ）。针对这种单克隆免疫球蛋白产生的特异性抗独特型血清与母亲血清以及其他弓形虫抗体阳性血清均无反应。新生儿血清中的弓形虫抗体局限于IgG-λ，但未发现单克隆部分负责抗体活性的证据。
