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利用微型计算机为接受大手术的血友病患者计算连续的因子VIII剂量。

Successive factor VIII doses for a haemophiliac undergoing major surgery calculated on a micro-computer.

作者信息

Duncan B, Lloyd J, Lesnikowski E

出版信息

Thromb Haemost. 1982 Feb 26;47(1):66-8.

PMID:6803383
Abstract

Doses of factor VIII to be infused into a haemophiliac undergoing major surgery were calculated on a micro-computer. The degree to which the particular patient responded to infused factor VIII and the rate at which it decayed were estimated by two pre-operative experiments. Plasma levels of factor VIII were predicted over fourteen days during which time the patient was infused with 53,000 iu. A continuous plot of predicted values with time was displayed on a video monitor. The predicted values showed good agreement with assay results.

摘要

通过微型计算机计算出要输入接受大手术的血友病患者体内的凝血因子VIII剂量。通过两项术前实验评估特定患者对输入的凝血因子VIII的反应程度及其衰减速率。预测了患者在接受53,000国际单位输入的十四天内凝血因子VIII的血浆水平。预测值随时间的连续曲线显示在视频监视器上。预测值与检测结果吻合良好。

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Successive factor VIII doses for a haemophiliac undergoing major surgery calculated on a micro-computer.利用微型计算机为接受大手术的血友病患者计算连续的因子VIII剂量。
Thromb Haemost. 1982 Feb 26;47(1):66-8.
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引用本文的文献

1
Pharmacokinetics of coagulation factors: clinical relevance for patients with haemophilia.凝血因子的药代动力学：对血友病患者的临床意义
Clin Pharmacokinet. 2001;40(11):815-32. doi: 10.2165/00003088-200140110-00003.
2
Multi-variate analysis of factors governing the pharmacokinetics of exogenous factor VIII in haemophiliacs.
Eur J Clin Pharmacol. 1988;35(6):663-8. doi: 10.1007/BF00637604.
3
Clinical pharmacokinetics of factor VIII in patients with classic haemophilia.
Clin Pharmacokinet. 1987 Dec;13(6):365-80. doi: 10.2165/00003088-198713060-00002.