经典血友病患者对抗血友病因子浓缩物输注反应的研究。通过促凝血和免疫技术测定的抗血友病因子半衰期的差异。
Studies on the response of patients with classic hemophilia to transfusion with concentrates of antihemophilic factor. A difference in the half-life of antihemophilic factor as measured by procoagulant and immunologic techniques.
作者信息
Bennett B, Ratnoff O D
出版信息
J Clin Invest. 1972 Oct;51(10):2593-6. doi: 10.1172/JCI107076.
Abstract
Antihemophilic factor (AHF, factor VIII) levels were measured by a standard coagulation method and by an immunologic technique before and after infusion of AHF concentrates into patients with classic hemophilia. After infusion of AHF concentrates, the half-life of the AHF procoagulant (i.e., clot-promoting) activity varied from 12 to 14 hr, whereas that of the antigen ranged from 24 to 40 hr. The half-life of the antigen was similar in patients with and without circulating anticoagulants to AHF. The data are compatible with the suggestion that the antigen may be carried on a precursor molecule which the patient with hemophilia produces but cannot convert to the functional clot-promoting agent. Other explanations of the observations are, however, recognized.
摘要
采用标准凝血方法和免疫技术，在向典型血友病患者输注抗血友病因子（AHF，因子VIII）浓缩物之前和之后，测定AHF水平。输注AHF浓缩物后，AHF促凝（即促凝块形成）活性的半衰期为12至14小时，而抗原的半衰期为24至40小时。有无AHF循环抗凝剂的患者中，抗原的半衰期相似。这些数据与以下观点相符：抗原可能存在于一种前体分子上，血友病患者能够产生这种前体分子，但无法将其转化为具有功能的促凝剂。然而，这些观察结果也存在其他解释。
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Studies on the response of patients with classic hemophilia to transfusion with concentrates of antihemophilic factor. A difference in the half-life of antihemophilic factor as measured by procoagulant and immunologic techniques.经典血友病患者对抗血友病因子浓缩物输注反应的研究。通过促凝血和免疫技术测定的抗血友病因子半衰期的差异。
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THE FATE OF PROTHROMBIN AND FACTORS VIII, IX AND X TRANSFUSED TO PATIENTS DEFICIENT IN THESE FACTORS.凝血酶原以及凝血因子VIII、IX和X输注给缺乏这些因子的患者后的转归
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