Rotblat F, Hawkey C, O'Brien D P, Tuddenham E G
Thromb Res. 1982 Mar 1;25(5):423-31. doi: 10.1016/0049-3848(82)90132-3.
Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was parallel in all cases. Factor VIII-related antigen (VIIIR:Ag) measured using rabbit antibody to human VIIIR:Ag was low or absent in most species except simians and the dose response curve was non-parallel to the human standard except with goat plasma. Avians lacked cross-reactive material.
已在一系列脊椎动物门类中检测了与凝血因子VIII交叉反应的抗原。使用人抗体检测的VIII凝血抗原（VIII:CAg）通常远低于所报道的VIII凝血活性（VIII:C）值，但猿猴和豚鼠除外。在所有情况下，该检测的剂量反应曲线都是平行的。使用兔抗人VIII相关抗原（VIIIR:Ag）抗体检测的VIIIR:Ag在除猿猴外的大多数物种中含量较低或不存在，并且除山羊血浆外，剂量反应曲线与人类标准不平行。禽类缺乏交叉反应物质。
