Tikkanen M J, Nikkilä E A, Kuusi T, Sipinen S
Acta Endocrinol (Copenh). 1982 Apr;99(4):630-5. doi: 10.1530/acta.0.0990630.
The effects of oestradiol and levonorgestrel on plasma lipoprotein cholesterol (Chol) and triglyceride (Tg) levels and on postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activity were studied in 52 normolipoproteinaemic women. The androgen-derived progestin levonorgestrel increased postheparin plasma hepatic lipase (PH-HL) activity and decreased plasma high-density lipoprotein (HDL) lipid concentrations in a manner opposite to that of oestradiol. The relationships between PH-HL activity and HDL lipids suggest an important role for this enzyme as a mediator of sex hormone action on HDL.
在52名血脂正常的女性中研究了雌二醇和左炔诺孕酮对血浆脂蛋白胆固醇（Chol）和甘油三酯（Tg）水平以及对肝素后血浆脂蛋白脂肪酶（LPL）和肝脂肪酶（HL）活性的影响。雄激素衍生的孕激素左炔诺孕酮增加了肝素后血浆肝脂肪酶（PH-HL）活性，并以与雌二醇相反的方式降低了血浆高密度脂蛋白（HDL）脂质浓度。PH-HL活性与HDL脂质之间的关系表明该酶作为性激素对HDL作用的介质具有重要作用。
