Larrue J, Leroux C, Daret D, Bricaud H
Biochim Biophys Acta. 1982 Mar 12;710(3):257-63. doi: 10.1016/0005-2760(82)90107-2.
Prostaglandin synthesis in aortic smooth muscle cells originating from healthy an atherosclerotic rabbits was studied by incubating [14C]arachidonic acid with intact confluent cells and cell homogenates. In spite of a reduced 6-keto prostaglandin F1 alpha formation, no potentiating effect on the prostaglandin E2 generation occurred. Indeed, both cyclooxygenase and prostaglandin I2 synthetase activities appear to be reduced. These results suggest that an impaired arachidonic acid utilisation in aortic smooth muscle cells may be involved in the course of the atherosclerotic process.
通过将[14C]花生四烯酸与完整的融合细胞和细胞匀浆一起孵育，研究了源自健康和动脉粥样硬化兔子的主动脉平滑肌细胞中的前列腺素合成。尽管6-酮前列腺素F1α的生成减少，但对前列腺素E2的生成没有增强作用。实际上，环氧化酶和前列腺素I2合成酶的活性似乎都降低了。这些结果表明，主动脉平滑肌细胞中花生四烯酸利用受损可能参与了动脉粥样硬化过程。
