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[他莫昔芬诱导荧光作为激素受体的标志物:对接受治疗的女性恶性乳腺肿瘤细针穿刺活检的细胞学研究]

[Tamoxifen induced fluorescence as a marker of hormone receptors: cytological study of fine needle biopsy of malignant breast tumors in treated women].

作者信息

Mouriquand J, Mouriquand C, Sage J C, Saez S, Jacrot M, Gabelle P

出版信息

C R Seances Acad Sci III. 1981 Dec 21;293(15):801-6.

PMID:6804016
Abstract

Tamoxifen-induced fluorescence was used as a marker of hormone receptors in breast tumor cytology. Patients receiving Tamoxifen were compared to patients without such a therapy. Only those receiving this treatment showed fluorescence in their malignant cells. Moreover, in this group, such a fluorescence was noticed only in those patients with hormonal receptors in their tumor cells and not in the patients without estrogen and progesterone receptors. Such a technique seems to be a good method for predicting response to hormonal therapy.

摘要

他莫昔芬诱导的荧光被用作乳腺肿瘤细胞学中激素受体的标志物。将接受他莫昔芬治疗的患者与未接受这种治疗的患者进行比较。只有接受这种治疗的患者在其恶性细胞中显示出荧光。此外,在这组患者中,仅在肿瘤细胞中有激素受体的患者中观察到这种荧光,而在没有雌激素和孕激素受体的患者中未观察到。这种技术似乎是预测激素治疗反应的一种好方法。

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