钼酸盐、钨酸盐和lxd对黑腹果蝇中醛氧化酶和黄嘌呤脱氢酶的影响。

The effects of molybate, tungstate and lxd on aldehyde oxidase and xanthine dehydrogenase in Drosophila melanogaster.

作者信息

Bentley M M, Williamson J H, Oliver M J

出版信息

Can J Genet Cytol. 1981;23(4):597-609. doi: 10.1139/g81-066.

Abstract

The effects of dietary sodium molybdate and sodium tungstate on eye color and aldehyde oxidase and xanthine dehydrogenase activities have been determined in Drosophila melanogaster. Dietary sodium tungstate administration has been used as a screening procedure to identify two new lxd alleles. Tungstate administration results in increased frequencies of "brown-eyed" flies in lxd stocks and a coordinate decrease in AO and XDH activities in all genotypes tested. The two new lxd alleles affect AO and XDH in a qualitatively but not quantitatively similar fashion to the original lxd allele. AO and XDH activity and AO-CRM levels appear much more sensitive to mutational perturbations of this gene-enzyme than do XDH-CRM levels in the genotypes tested.

摘要

已在黑腹果蝇中测定了饮食中钼酸钠和钨酸钠对眼色、醛氧化酶和黄嘌呤脱氢酶活性的影响。饮食中添加钨酸钠已被用作一种筛选程序，以鉴定两个新的lxd等位基因。施用钨酸钠会导致lxd品系中“褐眼”果蝇的频率增加，并且在所有测试基因型中，醛氧化酶（AO）和黄嘌呤脱氢酶（XDH）的活性协同降低。这两个新的lxd等位基因对AO和XDH的影响在性质上与原始lxd等位基因相似，但在数量上不同。在所测试的基因型中，AO和XDH活性以及AO - CRM水平似乎比XDH - CRM水平对该基因 - 酶的突变扰动更为敏感。