Ng W S, Chau P Y
Chemotherapy. 1982;28(2):105-9. doi: 10.1159/000238064.
Chloramphenicol and thiamphenicol were tested by the agar dilution method against 105 Salmonella typhi, 15 S. paratyphi A, 6 S. paratyphi B, 8 S. paratyphi c, 57 Haemophilus influenzae and 60 Neisseria gonorrhoeae strains. The two drugs showed similar in vitro activity against strains of H. influenzae and N. gonorrhoeae irrespective of their beta-lactamase production. In contrast, while all the tested isolatels of typhoid and paratyphoid fever Salmonella were susceptible to chloramphenicol, most of these strains showed resistance to thiamphenicol with MICs greater than or equal to 8 microgram/ml. The significance of these findings are discussed.
采用琼脂稀释法，用氯霉素和甲砜霉素对105株伤寒沙门菌、15株甲型副伤寒沙门菌、6株乙型副伤寒沙门菌、8株丙型副伤寒沙门菌、57株流感嗜血杆菌和60株淋病奈瑟菌进行了检测。这两种药物对流感嗜血杆菌和淋病奈瑟菌菌株显示出相似的体外活性，无论它们是否产生β-内酰胺酶。相比之下，虽然所有检测的伤寒和副伤寒热沙门菌分离株对氯霉素敏感，但这些菌株中的大多数对甲砜霉素耐药，其最低抑菌浓度大于或等于8微克/毫升。讨论了这些发现的意义。
