脂氧合酶抑制剂对葡萄糖诱导的胰岛素分泌的预防作用

Prevention of glucose-induced insulin secretion by lipoxygenase inhibitor.

作者信息

Yamamoto S, Nakadate T, Nakaki T, Ishii K, Kato R

出版信息

Eur J Pharmacol. 1982 Feb 26;78(2):225-7. doi: 10.1016/0014-2999(82)90240-0.

Abstract

Glucose-induced insulin secretion was investigated using isolated pancreatic islets of rats. The phospholipase A2 inhibitors. p-bromophenacyl bromide (0.1 mM) and mepacrine (0.1 mM) inhibited glucose-induced insulin secretion. Indomethacin (5 microM), a cyclooxygenase inhibitor, failed to inhibit glucose-induced insulin secretion, while the lipoxygenase inhibitor nordihydroguaiaretic acid (0.1-0.2 mM) inhibited it. These results suggest that stimulation of phospholipase A2 and a product(s) formed by the lipoxygenase pathway play an important role in the glucose-induced insulin secretion.

摘要

利用大鼠分离的胰岛研究了葡萄糖诱导的胰岛素分泌。磷脂酶A2抑制剂对溴苯甲酰溴（0.1 mM）和米帕林（0.1 mM）抑制了葡萄糖诱导的胰岛素分泌。环氧化酶抑制剂吲哚美辛（5 microM）未能抑制葡萄糖诱导的胰岛素分泌，而脂氧合酶抑制剂去甲二氢愈创木酸（0.1 - 0.2 mM）则抑制了该分泌。这些结果表明，磷脂酶A2的刺激以及脂氧合酶途径形成的一种或多种产物在葡萄糖诱导的胰岛素分泌中起重要作用。