一种新型化合物（E）-1-（4'-溴-4-联苯基）-1-（4-氯苯基）-3-二甲基氨基丙-1-烯对小鼠克氏锥虫的疗效。
The efficacy of a novel compound, (e)-1-(4'-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene against Trypanosoma cruzi in mice.
作者信息
Barrett P A, Beveridge E, Bull D, Caldwell I C, Islip P J, Neal R A, Woods N C
出版信息
Experientia. 1982 Mar 15;38(3):338-9. doi: 10.1007/BF01949378.
PMID:6804255
Abstract
The biological properties of a novel compound 353C with high activity against Trypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C has a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals.
摘要
描述了一种对克氏锥虫具有高活性的新型化合物353C的生物学特性。在使小鼠实现根治性治愈方面，该化合物分别比苯并硝唑或硝呋莫司有效约10倍和20倍。353C具有较长的半衰期，当每周给小鼠给药时显示出抗锥虫特性。
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