Realdi G, Alberti A, Rugge M, Rigoli A M, Tremolada F, Schivazappa L, Ruol A
Gut. 1982 Apr;23(4):270-5. doi: 10.1136/gut.23.4.270.
The long-term outcome of non-A, non-B post-transfusion hepatitis was evaluated in 21 patients who developed the illness after open-heart surgery and could be followed thereafter up to five years. Histological chronic sequelae were documented in 13 patients, and consisted of chronic persistent hepatitis in one case, chronic lobular hepatitis in two and chronic active hepatitis in 10, five of whom also developed superimposed cirrhosis. Progression to these chronic states was in most cases symptomless, independently of the severity of liver lesions; one patient, however, died of gastrointestinal bleeding due to cirrhosis of the liver. During follow-up the biochemical pattern of chronic non-A, non-B hepatitis was unique, while striking fluctuations of transaminase levels. Liver histology proved essential to identify the severity of chronic liver lesions, as clinical and biochemical features were uniform and not indicative of it. Our results suggest that cirrhosis may develop, often with an asymptomatic course, in a significant number of patients who do not recover after acute post-transfusion non-A, non-B hepatitis.
对21例在心脏直视手术后发生非甲非乙型输血后肝炎且此后可随访长达5年的患者的长期预后进行了评估。13例患者记录有组织学慢性后遗症，包括1例慢性持续性肝炎、2例慢性小叶性肝炎和10例慢性活动性肝炎，其中5例还并发了肝硬化。在大多数情况下，进展为这些慢性状态是无症状的，与肝脏病变的严重程度无关；然而，有1例患者死于肝硬化所致的胃肠道出血。在随访期间，慢性非甲非乙型肝炎的生化模式独特，转氨酶水平有显著波动。肝脏组织学对于确定慢性肝脏病变的严重程度至关重要，因为临床和生化特征较为一致，无法提示病变严重程度。我们的结果表明，在大量急性输血后非甲非乙型肝炎未恢复的患者中，可能会发生肝硬化，且通常病程无症状。
