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六种非人类灵长类动物的补体成分C3、C4和B因子

Complement components C3, C4, and Bf in six nonhuman primate species.

作者信息

McMahan M R

出版信息

Lab Anim Sci. 1982 Feb;32(1):57-9.

PMID:6804713
Abstract

The extent of cross reactivity between antisera to human complement proteins [the third (C3) and fourth (C4) components and factor B (Bf)] and these proteins in the sera of six species of nonhuman primates was examined. Strong cross reactivity was found with these antisera and the specific complement proteins from rhesus monkeys, stumptailed macaques, cynomolgus macaques, patas monkeys, African green monkeys, and squirrel monkeys. Although molecular differences were apparent as indicated by differences in antigenic determinants and electrophoretic mobility, the antisera developed against human C3, C4, and Bf could be used to identify and to characterize these proteins in the nonhuman primate species examined.

摘要

检测了抗人补体蛋白(第三成分C3、第四成分C4和B因子Bf)的抗血清与6种非人灵长类动物血清中这些蛋白之间的交叉反应程度。发现这些抗血清与恒河猴、短尾猕猴、食蟹猕猴、豚尾猴、非洲绿猴和松鼠猴的特异性补体蛋白有强烈的交叉反应。尽管抗原决定簇和电泳迁移率的差异表明存在分子差异,但针对人C3、C4和Bf产生的抗血清可用于鉴定和表征所检测的非人灵长类动物物种中的这些蛋白。

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引用本文的文献

1
The major histocompatibility complex of primates.灵长类动物的主要组织相容性复合体。
Genetica. 1987 Aug 31;73(1-2):53-68. doi: 10.1007/BF00057437.