重复电休克对正常大鼠生长激素分泌及可乐定刺激生长激素反应的影响

The effect of repeated electroconvulsive shocks on growth hormone secretion and growth hormone responses to clonidine in the intact rat.

作者信息

Steiner J A, Evans G, Grahame-Smith D G

出版信息

Psychopharmacology (Berl). 1982;76(1):98-100. doi: 10.1007/BF00430767.

Abstract

The effect of repeated electroconvulsive shocks (ECS) on growth hormone (GH) secretion was studied in rats. Male Sprague-Dawley animals were given one ECS daily for 10 days under halothane anaesthesia. Control animals were anaesthetised only. GH secretion was studied 24 h after the last ECS or sham procedure. Background GH secretion was significantly greater in ECS-treated than in sham-treated animals (P less than 0.001). The GH response to IV clonidine (0.01--0.1 mg/kg) did not differ between the two groups. The size of the GH response was not directly related to the basal GH secretion and could not be explained in terms of it.

摘要

研究了反复电惊厥休克（ECS）对大鼠生长激素（GH）分泌的影响。在氟烷麻醉下，对雄性斯普拉格-道利大鼠每天进行一次ECS，持续10天。对照动物仅进行麻醉。在最后一次ECS或假手术24小时后研究GH分泌。接受ECS治疗的动物的基础GH分泌显著高于接受假手术治疗的动物（P<0.001）。两组对静脉注射可乐定（0.01--0.1mg/kg）的GH反应无差异。GH反应的大小与基础GH分泌无直接关系，也无法用基础GH分泌来解释。