Johnstone E C, Deakin J F, Lawler P, Frith C D, Stevens M, McPherson K, Crow T J
Lancet. 1980;2(8208-8209):1317-20. doi: 10.1016/s0140-6736(80)92393-4.
70 patients with endogenous depression, defined by strict criteria, who fulfilled the Newcastle indications for electroconvulsive therapy (ECT) were randomly allocated either to a course of eight simulated ECTs or to a course of eight real ECTs. The improvement in terms of psychiatrists' ratings in the group of patients given real ECT was significantly greater (p < 0.01) than that in those given simulated ECT, but the difference between the two groups was small in relation to the considerable improvement of both groups over the 4-week treatment period. No differences were found between the two groups at one-month and six-month follow-up. The therapeutic benefits of electrically induced convulsions in depression were of lesser magnitude and were more transient than has sometimes been claimed. In the real-ECT group memory was impaired during treatment but memory tests revealed no difference between the groups at six-month follow-up.
70名符合严格标准的内源性抑郁症患者，满足纽卡斯尔电休克治疗（ECT）指征，被随机分配接受8次模拟ECT治疗或8次真实ECT治疗。接受真实ECT治疗的患者组，精神科医生评定的改善程度显著大于（p < 0.01）接受模拟ECT治疗的患者组，但两组之间的差异相对于两组在4周治疗期内的显著改善而言较小。在1个月和6个月随访时，两组之间未发现差异。电诱发惊厥对抑郁症的治疗益处程度较小且比有时声称的更短暂。在真实ECT组中，治疗期间记忆受到损害，但记忆测试显示在6个月随访时两组之间没有差异。
