Rochat C, Cervo L, Romandini S, Samanin R
Psychopharmacology (Berl). 1982;76(2):188-92. doi: 10.1007/BF00435276.
The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of d-fenfluramine on both responses on the hot plate were prevented by pretreatment with metergoline, a serotonin antagonist, whereas this pretreatment only reduced the effect of morphine on paw licking. The inhibition of tail withdrawal by morphine was also significantly reduced by metergoline treatment. The results confirm previous findings suggesting a role of serotonin in the mechanism by which morphine inhibits some nociceptive responses in rats. They also show that d-fenfluramine, a selective releaser and uptake inhibitor of serotonin at nerve endings, does not completely reproduce the antinociceptive effects of morphine in this species.
研究了右旋芬氟拉明和吗啡对大鼠各种伤害性反应的影响。与抑制所有所检测反应的吗啡不同，右旋芬氟拉明抑制大鼠在热板上的跳跃和舔爪行为，但并未增加其从热水中撤回尾巴的潜伏期。5-羟色胺拮抗剂美替拉酮预处理可预防右旋芬氟拉明对热板上这两种反应的影响，而该预处理仅能减弱吗啡对舔爪行为的作用。美替拉酮处理也能显著减弱吗啡对尾巴撤回的抑制作用。这些结果证实了先前的研究发现，提示5-羟色胺在吗啡抑制大鼠某些伤害性反应的机制中发挥作用。它们还表明，作为神经末梢5-羟色胺的选择性释放剂和摄取抑制剂，右旋芬氟拉明并不能完全重现吗啡在该物种中的镇痛作用。
