Haughton V M, Ho K C
Radiology. 1982 Jun;143(3):699-702. doi: 10.1148/radiology.143.3.6805038.
Arachnoiditis resulting from administration of intrathecal iophendylate (Pantopaque) was compared with that from metrizamide (Amipaque) in 16 monkeys. Four animals initially underwent metrizamide myelography, eight underwent iophendylate myelography, and four control animals received only cerebrospinal fluid. Twelve weeks later, all 16 animals underwent metrizamide myelography and then histologic studies. Animals receiving iophendylate for the first myelogram differed significantly from the other two groups on inflammation, fibrosis, and myelographic evidence of arachnoiditis. The arachnoiditis produced by iophendylate was more severe than that produced by metrizamide; the iophendylate also produced a more cellular reaction that was qualitatively different from the reaction to metrizamide. This more severe reaction to iophendylate has clinical implications for patients undergoing myelography if the contrast medium is not completely removed from the system after myelography.
在16只猴子中，对鞘内注射碘苯酯（潘托帕克）所致的蛛网膜炎与甲泛葡胺（阿米培克）所致的蛛网膜炎进行了比较。4只动物最初接受甲泛葡胺脊髓造影，8只接受碘苯酯脊髓造影，4只对照动物仅接受脑脊液。12周后，所有16只动物均接受甲泛葡胺脊髓造影，然后进行组织学研究。首次脊髓造影接受碘苯酯的动物在炎症、纤维化和蛛网膜炎的脊髓造影证据方面与其他两组有显著差异。碘苯酯所致的蛛网膜炎比甲泛葡胺所致的更严重；碘苯酯还产生了更明显的细胞反应，在性质上不同于对甲泛葡胺的反应。如果脊髓造影后造影剂未完全从体内清除，这种对碘苯酯更严重的反应对接受脊髓造影的患者具有临床意义。
