Bruguera M, Aranguibel F, Ros E, Rodés J
Gastroenterology. 1978 Sep;75(3):474-8.
In a review of 906 consecutive liver biopsies, sinusoidal dilatation, unrelated to passive congestion of the liver, sinusoidal infiltration, or cirrhosis, was found in 26 cases (2.9%). In 21 of them the final diagnosis was a neoplastic or granulomatous disease (tuberculosis, brucellosis, Crohn's disease), but in only half of them was there evidence of neoplastic or granulomatous infiltration of the liver. In the remaining cases, sinusoidal dilatation was either the only histological abnormality or it was associated with nonspecific changes. Although the pathogenesis of sinusoidal ectasia is not known, our findings indicate a definite relationship to the presence of tumor or granulomatous disease in the liver or elsewhere in the body. It is concluded that the finding of sinusoidal dilatation as an isolated histological change in a liver biopsy specimen should prompt the search for a tumor or a disease associated with granulomas.
在对906例连续肝脏活检的回顾中，发现26例（2.9%）存在与肝被动性充血、窦性浸润或肝硬化无关的窦性扩张。其中21例最终诊断为肿瘤性或肉芽肿性疾病（结核病、布鲁氏菌病、克罗恩病），但只有一半病例有肝脏肿瘤性或肉芽肿性浸润的证据。在其余病例中，窦性扩张要么是唯一的组织学异常，要么与非特异性改变相关。虽然窦性扩张的发病机制尚不清楚，但我们的研究结果表明其与肝脏或身体其他部位存在肿瘤或肉芽肿性疾病有明确关系。结论是，在肝活检标本中发现窦性扩张作为孤立的组织学改变应促使寻找与肉芽肿相关的肿瘤或疾病。
