冠心病的潜伏期。
Incubation period of coronary heart disease.
作者信息
Rose G
出版信息
Br Med J (Clin Res Ed). 1982 May 29;284(6329):1600-1. doi: 10.1136/bmj.284.6329.1600.
Abstract
Serum cholesterol concentrations and blood pressure were measured during 1958-64 among men aged 40-59 who took part in the Seven Countries Study. In the present study these measurements were related to the national mortality from coronary heart disease in the periods 1959-61, 1964-6, 1969-71, and 1974-6. The correlations increased with time (r = +0.86, 0.90, 0.93, and 0.96 respectively for serum cholesterol concentration and r = +0.48, 0.56, 0.57, and 0.64 for systolic blood pressure), suggesting that the "incubation period" between exposure to major coronary risk factors and the maximum effects on mortality may be 10 years or more.
摘要
1958年至1964年间，对参与七国研究的40至59岁男性的血清胆固醇浓度和血压进行了测量。在本研究中，这些测量结果与1959年至1961年、1964年至1966年、1969年至1971年以及1974年至1976年期间各国冠心病死亡率相关。相关性随时间增加（血清胆固醇浓度的相关系数分别为+0.86、0.90、0.93和0.96，收缩压的相关系数分别为+0.48、0.56、0.57和0.64），这表明接触主要冠心病危险因素与对死亡率产生最大影响之间的“潜伏期”可能为10年或更长时间。
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