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欧洲男同性恋者中的严重获得性免疫缺陷

Severe acquired immunodeficiency in European homosexual men.

作者信息

Gerstoft J, Malchow-Møller A, Bygbjerg I, Dickmeiss E, Enk C, Halberg P, Haahr S, Jacobsen M, Jensen K, Mejer J, Nielsen J O, Thomsen H K, Søndergaard J, Lorenzen I

出版信息

Br Med J (Clin Res Ed). 1982 Jul 3;285(6334):17-9. doi: 10.1136/bmj.285.6334.17.

DOI:10.1136/bmj.285.6334.17
PMID:6805793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1499130/
Abstract

Four previously healthy Danish homosexual men developed Kaposi's sarcoma or opportunistic infections with fever of unknown origin and lymphadenopathy. One patient died of a Pneumocystis carinii pneumonia. Three patients had defective cell-mediated immunity with absent leucocyte interferon production and decreased proliferative response to mitogens and antigens. T lymphocyte helper subsets and natural killer cell activity were reduced. Unstimulated mononuclear cells produced leucocyte migration inhibitor factor. Two patients were sexual partners and three had never been to the USA, where cases of severe acquired immunodeficiency have been reported. Thus, the syndrome must also be suspected in European homosexual men who present with fever of unknown origin, opportunistic infections, or Kaposi's sarcoma.

摘要

四名先前健康的丹麦同性恋男子患上了卡波西肉瘤或出现了不明原因发热和淋巴结病的机会性感染。一名患者死于卡氏肺孢子虫肺炎。三名患者细胞介导免疫功能缺陷，白细胞干扰素产生缺失，对有丝分裂原和抗原的增殖反应降低。T淋巴细胞辅助亚群和自然杀伤细胞活性降低。未受刺激的单核细胞产生白细胞迁移抑制因子。两名患者是性伴侣，三名患者从未去过美国，而美国曾报告过严重获得性免疫缺陷病例。因此，对于出现不明原因发热、机会性感染或卡波西肉瘤的欧洲同性恋男子，也必须怀疑患有该综合征。

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Severe acquired immunodeficiency in European homosexual men.欧洲男同性恋者中的严重获得性免疫缺陷
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本文引用的文献

1
Epidemiologic aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections.卡波西肉瘤当前疫情及机会性感染的流行病学方面
N Engl J Med. 1982 Jan 28;306(4):248-52. doi: 10.1056/NEJM198201283060431.
2
An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction.社区获得性卡氏肺孢子虫肺炎暴发：细胞免疫功能障碍的初始表现。
N Engl J Med. 1981 Dec 10;305(24):1431-8. doi: 10.1056/NEJM198112103052402.
3
Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions.男性同性恋者中严重的获得性免疫缺陷，表现为慢性肛周单纯疱疹溃疡性病变。
N Engl J Med. 1981 Dec 10;305(24):1439-44. doi: 10.1056/NEJM198112103052403.
4
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N Engl J Med. 1981 Dec 10;305(24):1425-31. doi: 10.1056/NEJM198112103052401.
5
Pneumocystis pneumonia--Los Angeles.肺孢子菌肺炎——洛杉矶
MMWR Morb Mortal Wkly Rep. 1981 Jun 5;30(21):250-2.
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Cellular and humoral immunity in Hodgkin's disease. I Patients in continuous long-term remission.霍奇金病的细胞免疫和体液免疫。I. 持续长期缓解的患者
Scand J Haematol. 1981 Sep;27(3):171-80. doi: 10.1111/j.1600-0609.1981.tb00469.x.
7
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Lancet. 1982 Feb 20;1(8269):412-6. doi: 10.1016/s0140-6736(82)91617-8.
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Lancet. 1981 Dec 12;2(8259):1339. doi: 10.1016/s0140-6736(81)91353-2.
9
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Lancet. 1981 Sep 19;2(8247):598-600. doi: 10.1016/s0140-6736(81)92740-9.
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