精子对去唾液酸GM1抗体的诱导及其在获得性免疫缺陷综合征（艾滋病）同性恋男性血清中的出现。
Induction of antibody to asialo GM1 by spermatozoa and its occurrence in the sera of homosexual men with the acquired immune deficiency syndrome (AIDS).
作者信息
Witkin S S, Sonnabend J, Richards J M, Purtilo D T
出版信息
Clin Exp Immunol. 1983 Nov;54(2):346-50.
Compared to healthy homosexual and heterosexual men, homosexual men with acquired immune deficiency syndrome (AIDS) possessed significantly higher levels of IgG antibody to the neutral glycolipid asialo GM1 (ganglio-N-tetraosylceramide) (P less than 0.01). Of 31 homosexuals with AIDS, 36% possessed levels of this antibody that were at least two standard deviations above the mean of the healthy men. Furthermore, asialo GM1 antibody could be removed from serum by adsorption with spermatozoa. Weekly rectal insemination of male rabbits with rabbit semen also led to the appearance of antibody to asialo GM1 by 15 weeks. These results suggest that asialo GM1 is a component of ejaculated spermatozoa and demonstrate that rectal insemination by itself can lead to the production of antibodies to this glycolipid in the rabbit. In addition, asialo GM1 antibodies may be of value as a serological marker for the early detection of individuals with AIDS.
与健康的同性恋和异性恋男性相比，患有获得性免疫缺陷综合征（艾滋病）的同性恋男性体内针对中性糖脂脱唾液酸GM1（神经节苷脂-N-四糖神经酰胺）的IgG抗体水平显著更高（P小于0.01）。在31名患有艾滋病的同性恋者中，36%的人该抗体水平至少比健康男性的平均值高出两个标准差。此外，脱唾液酸GM1抗体可通过与精子吸附从血清中去除。每周用兔精液对雄性兔子进行直肠授精，到15周时也会导致出现针对脱唾液酸GM1的抗体。这些结果表明脱唾液酸GM1是射出精子的一个成分，并证明直肠授精本身可导致兔子体内产生针对这种糖脂的抗体。此外，脱唾液酸GM1抗体可能作为早期检测艾滋病患者的血清学标志物具有价值。
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