在封闭社区中控制化脓性链球菌流行所需的最低青霉素预防剂量。
Minimum amount of penicillin prophylaxis required to control Streptococcus pyogenes epidemic in closed community.
作者信息
Colling A, Kerr I, Maxted W R, Widdowson J P
出版信息
Br Med J (Clin Res Ed). 1982 Jul 10;285(6335):95-6. doi: 10.1136/bmj.285.6335.95.
Abstract
The prophylaxis required to control an epidemic of Streptococcus pyogenes throat infection in a junior detention centre has been reported. In a further epidemic an attempt was made to determine the minimum amount of penicillin required to control the outbreak. Oral penicillin (0.5 g) given as a single daily dose for 10 days to all boys after entry proved effective. The added risk of relatively deprived adolescent boys developing rheumatic fever is stressed.
摘要
据报道，在一所少年拘留中心为控制化脓性链球菌咽喉感染疫情所采取的预防措施。在另一次疫情中，人们试图确定控制疫情所需的最低青霉素剂量。对所有进入拘留中心的男孩每天口服一次青霉素（0.5克），持续10天，结果证明是有效的。文中强调了相对贫困的青少年男孩患风湿热的额外风险。
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本文引用的文献
1
Streptococcal infection in a Junior Detention Centre: a five-year study.少年拘留中心的链球菌感染：一项为期五年的研究。
J Hyg (Lond). 1980 Dec;85(3):331-41. doi: 10.1017/s0022172400063403.
2
Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis.
Lancet. 1980 Sep 6;2(8193):498-502. doi: 10.1016/s0140-6736(80)91832-2.
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