Roos K, Grahn E, Holm S E, Johansson H, Lind L
Ear, Nose, Throat Department, Lundy Hospital, Göteborg, Sweden.
Int J Pediatr Otorhinolaryngol. 1993 Jan;25(1-3):141-8. doi: 10.1016/0165-5876(93)90047-7.
Recurrent streptococcal tonsillitis/pharyngitis is a great problem, especially in certain epidemiological situations. Patients treated with antibiotics often have a disturbed normal throat flora and may lack, e.g., alpha-streptococci known in vitro to have an interfering activity against group A streptococci. Thirty-one patients with recurrent streptococcal tonsillitis were given antibiotics for 10 days. At the end of this treatment they were sprayed in their mouths with four selected alpha-streptococcal strains known to have strong growth inhibiting activity in vitro against most beta-streptococci group A. The follow-up period after this colonization was 3 months. After alpha-streptococcal treatment, none of the patients attracted a new tonsillitis during the follow-up period while 8% of the controls had a second tonsillitis. Treatment of streptococcal tonsillitis/pharyngitis with antibiotics followed by recolonization with alpha-streptococci seems to hinder further recurrences.
复发性链球菌性扁桃体炎/咽炎是一个严重的问题，尤其是在某些流行病学情况下。接受抗生素治疗的患者通常会出现正常咽喉菌群紊乱，可能会缺乏例如在体外已知对A组链球菌具有干扰活性的α-链球菌。31例复发性链球菌性扁桃体炎患者接受了10天的抗生素治疗。在该治疗结束时，给他们口腔喷洒四种选定的α-链球菌菌株，这些菌株在体外已知对大多数A组β-链球菌具有强大的生长抑制活性。这种定植后的随访期为3个月。经过α-链球菌治疗后，在随访期间没有患者出现新的扁桃体炎，而对照组中有8%的患者出现了第二次扁桃体炎。先用抗生素治疗链球菌性扁桃体炎/咽炎，然后再用α-链球菌重新定植，似乎可以阻止进一步复发。
