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[In vitro modification of the morphology and the growth of cells infected with scrapie (author's transl)].

作者信息

Markovits P, Dormont D, Maunoury R, Delamarche C, Delpech A, Dianoux L, Latarjet R

出版信息

C R Seances Acad Sci III. 1982 Feb 15;294(7):305-12.

PMID:6805865
Abstract

Seven cell lines originated either in brains or in neuroblastomas of Mice, were infected with Scrapie. After 12 to 16 in vitro passages, 6 lines out of 7 showed changes of their morphology, and of their growth, resembling those occurring in the course of a malignant transformation. The Scrapie infected cells acquired the capacity to form 2 to 4 times more colonies in liquid medium than the controls, and to develop large tridimensional colonies in semisolid medium. The role of Scrapie in these changes is discussed.

摘要

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