• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

辐射嵌合体对克氏锥虫的易感性。

Susceptibility of radiation chimeras to Trypanosoma cruzi.

作者信息

Trischmann T M

出版信息

Infect Immun. 1982 May;36(2):844-6. doi: 10.1128/iai.36.2.844-846.1982.

DOI:10.1128/iai.36.2.844-846.1982
PMID:6806196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC351307/
Abstract

Reciprocal bone marrow transfers were performed with C3H/HeJ mice, which are susceptible to infection with the Brazil strain of Trypanosoma cruzi, and resistant F1 (C3H/HeJ X C57BL/6J) mice. Mice reconstituted after lethal irradiation with syngeneic bone marrow displayed the resistance phenotype of the strain used, but neither C3H mice reconstituted with F1 bone marrow cells nor F1 mice reconstituted with C3H bone marrow cells survived challenge. Resistance to T. cruzi appears to be dependent upon factors associated both with host background and with bone marrow-derived cells.

摘要

用易感染克氏锥虫巴西株的C3H/HeJ小鼠和具有抗性的F1（C3H/HeJ×C57BL/6J）小鼠进行了相互骨髓移植。用同基因骨髓进行致死性照射后重建的小鼠表现出所用品系的抗性表型，但用F1骨髓细胞重建的C3H小鼠和用C3H骨髓细胞重建的F1小鼠在受到攻击后均未存活。对克氏锥虫的抗性似乎取决于与宿主背景和骨髓来源细胞相关的因素。

相似文献

1
Susceptibility of radiation chimeras to Trypanosoma cruzi.辐射嵌合体对克氏锥虫的易感性。
Infect Immun. 1982 May;36(2):844-6. doi: 10.1128/iai.36.2.844-846.1982.
2
Genetics of resistance to the African trypanosomes. IV. Resistance of radiation chimeras to Trypanosoma rhodesiense infection.
Cell Immunol. 1984 Aug;87(1):85-91. doi: 10.1016/0008-8749(84)90132-1.
3
Different cellular basis for the resistance of C3H and STS strain mice to the development of thymic lymphomas following fractionated whole-body irradiation: analysis using radiation bone marrow chimeras.C3H和STS品系小鼠在分次全身照射后对胸腺淋巴瘤发生具有抗性的不同细胞基础：利用辐射骨髓嵌合体进行的分析
Int J Radiat Biol. 2000 Aug;76(8):1105-11. doi: 10.1080/09553000050111578.
4
The nature of tolerance in adult recipient mice made tolerant of alloantigens with supralethal irradiation followed by syngeneic bone marrow cell transplantation plus injection of F1 spleen cells.成年受体小鼠通过超致死剂量照射后进行同基因骨髓细胞移植并注射F1脾细胞而对同种异体抗原产生耐受，其耐受的本质。
Transplantation. 1989 Jun;47(6):1021-9. doi: 10.1097/00007890-198906000-00021.
5
Genetics of murine resistance to Trypanosoma cruzi.小鼠对克氏锥虫抗性的遗传学
Infect Immun. 1982 Feb;35(2):546-51. doi: 10.1128/iai.35.2.546-551.1982.
6
Trypanosoma cruzi: regulation of mitogenic responses during infection in genetically resistant and susceptible inbred mouse strains.克氏锥虫：在遗传抗性和易感性近交小鼠品系感染期间有丝分裂反应的调节
Exp Parasitol. 1985 Feb;59(1):33-43. doi: 10.1016/0014-4894(85)90054-2.
7
Enhancement of BM allografting from C57BL/6 'nude' mice into C3H/HeJ recipients by tolerized T cells from (C57BL/6-->C3H/HeJ) and (C3H/HeJ-->C57BL/6) chimeras.通过来自（C57BL/6→C3H/HeJ）和（C3H/HeJ→C57BL/6）嵌合体的耐受T细胞增强从C57BL/6“裸”小鼠到C3H/HeJ受体的骨髓同种异体移植。
Bone Marrow Transplant. 1993 Jul;12(1):15-20.
8
Role of the thymus in control of autoreactivity or allotolerance in syngeneic and allogeneic bone marrow chimeras treated with bacterial adjuvants.胸腺在经细菌佐剂处理的同基因和异基因骨髓嵌合体中控制自身反应性或同种耐受中的作用。
J Immunol. 1984 Oct;133(4):1735-9.
9
Bone marrow transplantation from Fv-4-resistant donors rescues Friend leukemia virus-infected mice from leukemia: a model of bone marrow transplantation therapy against retroviral infection.来自Fv-4抗性供体的骨髓移植可使感染Friend白血病病毒的小鼠免于白血病：一种针对逆转录病毒感染的骨髓移植治疗模型。
Leukemia. 1994 Dec;8(12):2200-6.
10
Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice?
Res Immunol. 1991 Feb;142(2):117-22. doi: 10.1016/0923-2494(91)90019-f.

引用本文的文献

1
Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease.急性恰加斯病嵌合小鼠模型中骨髓细胞向心脏的迁移。
Mem Inst Oswaldo Cruz. 2017 Aug;112(8):551-560. doi: 10.1590/0074-02760160526.
2
The AXB and BXA set of recombinant inbred mouse strains.AXB和BXA系列重组近交系小鼠品系。
Mamm Genome. 1992;3(12):669-80. doi: 10.1007/BF00444361.

本文引用的文献

1
Genetics of murine resistance to Trypanosoma cruzi.小鼠对克氏锥虫抗性的遗传学
Infect Immun. 1982 Feb;35(2):546-51. doi: 10.1128/iai.35.2.546-551.1982.
2
Immunobiology of Trypanosoma cruzi infection and Chagas's disease.
Trans R Soc Trop Med Hyg. 1981;75(4):493-8. doi: 10.1016/0035-9203(81)90184-x.
3
Trypanosoma cruzi: in vivo and in vitro correlation between T-cell activation and susceptibility in inbred strains of mice.克氏锥虫：近交系小鼠体内及体外T细胞活化与易感性之间的相关性
Exp Parasitol. 1981 Jun;51(3):325-34. doi: 10.1016/0014-4894(81)90120-x.
4
Genetically determined differences in antibacterial activity of macrophages are expressed in the environment in which the macrophage precursors mature.巨噬细胞抗菌活性的基因决定差异在巨噬细胞前体成熟的环境中得以体现。
Cell Immunol. 1980 Aug 1;53(2):341-9. doi: 10.1016/0008-8749(80)90334-2.
5
Measurement of cytolytic antibody in experimental Chagas' disease using a terminal radiolabelling procedure.使用末端放射性标记程序测量实验性恰加斯病中的细胞溶解抗体。
J Parasitol. 1980 Jun;66(3):399-406.
6
Trypanosoma cruzi: ability of T-cell-enriched and -depleted lymphocyte populations to passively protect mice.
Exp Parasitol. 1980 Apr;49(2):225-32. doi: 10.1016/0014-4894(80)90119-8.
7
Genetically determined susceptibility to Leishmania tropica infection is expressed by haematopoietic donor cells in mouse radiation chimaeras.在小鼠辐射嵌合体中，造血供体细胞表现出对热带利什曼原虫感染的遗传决定易感性。
Nature. 1980 Nov 13;288(5787):161-2. doi: 10.1038/288161a0.
8
Inherited resistance to Corynebacterium kutscheri in mice.小鼠对库氏棒状杆菌的遗传性抗性。
Infect Immun. 1976 Aug;14(2):475-82. doi: 10.1128/iai.14.2.475-482.1976.
9
Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells.克氏锥虫：在哺乳动物细胞中的入侵机制及细胞内命运
J Exp Med. 1976 Jun 1;143(6):1402-20. doi: 10.1084/jem.143.6.1402.
10
Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice.小鼠对细菌感染的抵抗力和易感性：抗性或易感小鼠中李斯特菌病的病程
Infect Immun. 1978 Mar;19(3):763-70. doi: 10.1128/iai.19.3.763-770.1978.