Powell M R, Kuhn R E
J Parasitol. 1980 Jun;66(3):399-406.
The onset and development of anti-Trypanosoma cruzi cytolytic antibody during the course of infection were examined in two strains of mice that differ in their susceptibility to T. cruzi. The relative amounts of cytolytic antibody in the sera of mice were determined by a terminal radiolabeling procedure that measures the amount of 3H-thymidine incorporatedinto culture-form parasites that survive treatment with antibody and complement. The results showed that low levels of anti-T. cruzi cytolytic antibody developed during the course of infection in mice, and that there was no apparent difference in cytolytic antibody responses during the acute phase of infection in relatively resistant C57BL/6 mice and highly susceptible C3H(He)mice.
在对克氏锥虫易感性不同的两株小鼠感染过程中，检测了抗克氏锥虫溶细胞抗体的产生和发展。通过一种终末放射性标记程序来测定小鼠血清中溶细胞抗体的相对含量，该程序测量掺入到经抗体和补体处理后存活的培养型寄生虫中的3H-胸腺嘧啶核苷的量。结果显示，在小鼠感染过程中产生了低水平的抗克氏锥虫溶细胞抗体，并且在感染急性期，相对抗性的C57BL/6小鼠和高度易感的C3H(He)小鼠的溶细胞抗体反应没有明显差异。
