Matzkies F
Fortschr Med. 1978 Aug 24;96(32):1619-21.
In a collective of 3899 out-patients, the effect of uric acid reduction of benzbromarone was tested. Ten days after beginning of treatment, a uric acid concentration of 5.1 to 5.7 mg/100 ml had been obtained. Three months after beginning of therapy, uric acid values were at 4.9 mg/100 ml, independently of age and sex. As side-effects were observed:diarrhoea in 1% (n = 41) of the treated patients, furthermore, 0,8% (n = 31) complained of gastro-intestinal trouble such as pressure over the stomach, nausea, sensation of fullness and epigastric pain. Only in 2 of the 3899 patients (0.05%) the appearance of a renal colic was observed.
在3899名门诊患者群体中，测试了苯溴马隆降低尿酸的效果。治疗开始10天后，尿酸浓度达到了5.1至5.7毫克/100毫升。治疗开始三个月后，尿酸值为4.9毫克/100毫升，与年龄和性别无关。观察到的副作用有：1%（n = 41）的接受治疗患者出现腹泻，此外，0.8%（n = 31）抱怨有胃肠道不适，如胃部压迫感、恶心、饱腹感和上腹部疼痛。在3899名患者中，仅2名（0.05%）出现肾绞痛。
