Matzkies F, Berg G, Minzlaff R
Fortschr Med. 1977 Jul 21;95(27):1748-50.
By treating 16 hyperuricemic patients each with 25 and 50 mg of Benzbromarone a significant decrease of the uric acid concentration in the serum into the normal range is achieved. On the 5th and 6th day after beginning the treatment the dosage of 25 mg of Benzbromarone renders a morning value of 5,3 +/- 1,0 and an evening value of 5,0 +/- 0,9 mg/100 ml. After administration of 50 mg of Benzbromarone there is also prevailing a steady-state behaviour on the 5th and 6th day for the uric acid concentration in the serum. Thereby the morning value is 3,7 +/- 0,8 mg/100 ml and th evening value 3,4 +/- 0,9 mg/100 ml. After both dosages an increased urate elimination occurs initially during the 1st, 2nd and 3rd day after beginning of the therapy. However, after having achieved therapeutically reduced uric acid levels, the uric acid elimination from the 4th, 5th and 6th day partially ranges below those values existing before beginning of the therapy. During a chronic treatment no hyperuraturia can be observed on account of the therapeutically reduced serum concentrations. Consequently an increased risk towards a formation of urate calculi is not given under the long-term treatment.
通过分别用25毫克和50毫克苯溴马隆治疗16名高尿酸血症患者，可使血清尿酸浓度显著降低至正常范围。在开始治疗后的第5天和第6天，25毫克苯溴马隆的剂量使早晨值为5.3±1.0，晚上值为5.0±0.9毫克/100毫升。给予50毫克苯溴马隆后，在第5天和第6天血清尿酸浓度也呈现出稳定状态。此时早晨值为3.7±0.8毫克/100毫升，晚上值为3.4±0.9毫克/100毫升。两种剂量给药后，在治疗开始后的第1天、第2天和第3天最初都会出现尿酸排泄增加。然而，在治疗使尿酸水平降低后，从第4天、第5天和第6天开始，尿酸排泄部分低于治疗开始前的水平。在长期治疗期间，由于治疗使血清浓度降低，未观察到高尿酸尿症。因此，长期治疗下形成尿酸结石的风险不会增加。
