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Crossed immunoelectrophoresis of human platelet membranes. The major antigen consists of a complex of glycoproteins, GPIIb and GPIIIa, held together by Ca2+ and missing in Glanzmann's thrombasthenia.

作者信息

Howard L, Shulman S, Sadanandan S, Karpatkin S

出版信息

J Biol Chem. 1982 Jul 25;257(14):8331-6.

PMID:6806294
Abstract
摘要

相似文献

1
Crossed immunoelectrophoresis of human platelet membranes. The major antigen consists of a complex of glycoproteins, GPIIb and GPIIIa, held together by Ca2+ and missing in Glanzmann's thrombasthenia.人血小板膜的交叉免疫电泳。主要抗原由糖蛋白GPIIb和GPIIIa的复合物组成，该复合物由Ca2+维系在一起，在Glanzmann血小板无力症中缺失。
J Biol Chem. 1982 Jul 25;257(14):8331-6.
2
Glycoproteins of platelet membranes from Glanzmann's thrombasthenia. A comparison with normal using carbohydrate-specific or protein-specific labelling techniques and high-resolution two-dimensional gel electrophoresis.血小板无力症患者血小板膜糖蛋白。采用碳水化合物特异性或蛋白质特异性标记技术及高分辨率二维凝胶电泳与正常人进行比较。
Eur J Biochem. 1981 May 15;116(2):379-88. doi: 10.1111/j.1432-1033.1981.tb05346.x.
3
Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.单核细胞和血小板共享糖蛋白IIb和IIIa，而在I型Glanzmann血小板无力症中，这两种细胞均缺乏这些糖蛋白。
Biochem J. 1983 Aug 15;214(2):331-7. doi: 10.1042/bj2140331.
4
[Studies on released-ADP and membrane glycoprotein in platelets of patients with Glanzmann's thrombasthenia and essential athrombia (author's transl)].关于Glanzmann血小板无力症和原发性无血栓形成患者血小板中释放的二磷酸腺苷及膜糖蛋白的研究（作者译）
Rinsho Ketsueki. 1978 Oct;19(10):1306-13.
5
Aggregation of chymotrypsin-treated thrombasthenic platelets is mediated by fibrinogen binding to glycoproteins IIb and IIIa.经胰凝乳蛋白酶处理的血小板无力症血小板的聚集是由纤维蛋白原与糖蛋白IIb和IIIa结合介导的。
J Lab Clin Med. 1985 Dec;106(6):651-60.
6
Quantitation of platelet fibrinogen and thrombospondin in Glanzmann's thrombasthenia by electroimmunoassay.用电免疫分析法对血小板无力症患者血小板中的纤维蛋白原和血小板反应蛋白进行定量分析。
Thromb Res. 1989 Mar 15;53(6):521-33. doi: 10.1016/0049-3848(89)90142-4.
7
A variant of Glanzmann's thrombasthenia characterized by abnormal glycoprotein IIb/IIIa complex formation.一种以糖蛋白IIb/IIIa复合物形成异常为特征的Glanzmann血小板无力症变体。
Thromb Haemost. 1989 Nov 24;62(3):977-83.
8
Decreased stability and structural heterogeneity of the residual platelet glycoprotein IIb/IIIa complex in a variant of Glanzmann's thrombasthenia.在Glanzmann血小板无力症的一个变体中，残余血小板糖蛋白IIb/IIIa复合物的稳定性降低和结构异质性
Br J Haematol. 1989 Dec;73(4):514-21. doi: 10.1111/j.1365-2141.1989.tb00290.x.
9
Diversity of glycoprotein deficiencies in Glanzmann's thrombasthenia.血小板无力症中糖蛋白缺陷的多样性。
Thromb Haemost. 1985 Oct 30;54(3):626-9.
10
Crossed immunoelectrophoresis of human platelet membranes. Diminished major antigen in Glanzmann's thrombasthenia and Bernard-Soulier syndrome.人血小板膜的交叉免疫电泳。血小板无力症和巨大血小板综合征中主要抗原减少。
J Biol Chem. 1980 May 10;255(9):4320-7.

引用本文的文献

1
Anti-ethylene Diamine Tetra-Acetate (EDTA)-Induced Pseudothrombocytopenia in a Nigerian Middle-Aged Man.一名尼日利亚中年男性中抗乙二胺四乙酸（EDTA）诱导的假性血小板减少症
Cureus. 2025 Apr 23;17(4):e82864. doi: 10.7759/cureus.82864. eCollection 2025 Apr.
2
Discovery and Correction of Spurious Low Platelet Counts due to EDTA-Dependent Pseudothrombocytopenia.因乙二胺四乙酸（EDTA）依赖性假性血小板减少症导致的假性低血小板计数的发现与纠正
J Clin Lab Anal. 2015 Sep;29(5):419-26. doi: 10.1002/jcla.21818. Epub 2014 Nov 25.
3
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.
血小板糖蛋白IIb/IIIa（整合素αIIbβ3）的历程：一个受体由技术驱动的曲折传奇，甚至还有一个转折。
Blood. 2008 Oct 15;112(8):3011-25. doi: 10.1182/blood-2008-06-077891.
4
Diverse Lyme disease spirochetes bind integrin alpha IIb beta 3 on human platelets.多种莱姆病螺旋体可与人血小板上的整合素αIIbβ3结合。
Infect Immun. 1994 Dec;62(12):5559-67. doi: 10.1128/iai.62.12.5559-5567.1994.
5
A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets.一种对自身免疫性血小板减少症血小板反应性降低的单克隆抗血小板抗体。
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6992-5. doi: 10.1073/pnas.80.22.6992.
6
A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.一种能完全阻断纤维蛋白原与血小板结合的鼠单克隆抗体，可使正常血小板产生类血小板无力症状态，并与糖蛋白IIb和/或IIIa结合。
J Clin Invest. 1983 Jul;72(1):325-38. doi: 10.1172/jci110973.
7
Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets.血小板表面Ca2+高亲和力结合位点的鉴定及其功能
J Clin Invest. 1984 Mar;73(3):626-32. doi: 10.1172/JCI111252.
8
Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.单核细胞和血小板共享糖蛋白IIb和IIIa，而在I型Glanzmann血小板无力症中，这两种细胞均缺乏这些糖蛋白。
Biochem J. 1983 Aug 15;214(2):331-7. doi: 10.1042/bj2140331.
9
Retention of the glycoprotein IIb-IIIa complex in the isolated platelet cytoskeleton. Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons.糖蛋白IIb-IIIa复合物在分离的血小板细胞骨架中的保留。血小板伪足和收缩性细胞骨架可分离组装的影响。
J Clin Invest. 1984 Sep;74(3):1080-9. doi: 10.1172/JCI111475.
10
A variant of Glanzmann's thrombasthenia with abnormal glycoprotein IIb-IIIa complexes in the platelet membrane.一种血小板膜糖蛋白IIb-IIIa复合物异常的Glanzmann血小板无力症变体。
J Clin Invest. 1987 Mar;79(3):962-9. doi: 10.1172/JCI112907.