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单核细胞和血小板共享糖蛋白IIb和IIIa，而在I型Glanzmann血小板无力症中，这两种细胞均缺乏这些糖蛋白。

Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.

作者信息

Gogstad G, Hetland O, Solum N O, Prydz H

出版信息

Biochem J. 1983 Aug 15;214(2):331-7. doi: 10.1042/bj2140331.

DOI:10.1042/bj2140331
PMID:6225428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152252/
Abstract

By means of an antiserum specific to the complex of the platelet membrane glycoproteins IIb and IIIa we demonstrate here that monocytes and purified monocyte membranes share these glycoproteins with platelets. The monocyte glycoprotein IIb-IIIa complex showed complete immunological identity with the platelet counterpart and, furthermore, dissociated after EDTA treatment exactly as did the platelet complex. In Glanzmann's thrombasthenia type I, monocytes as well as platelets lack this antigen completely.

摘要

借助针对血小板膜糖蛋白IIb和IIIa复合物的特异性抗血清，我们在此证明单核细胞及纯化的单核细胞膜与血小板共享这些糖蛋白。单核细胞糖蛋白IIb - IIIa复合物与血小板中的对应物表现出完全的免疫同一性，此外，经EDTA处理后其解离情况与血小板复合物完全相同。在I型Glanzmann血小板无力症中，单核细胞和血小板均完全缺乏这种抗原。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/21c89811f58f/biochemj00344-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/591ea7d13631/biochemj00344-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/b7a81d524aa0/biochemj00344-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/dc6044d76bdc/biochemj00344-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/299013ee124f/biochemj00344-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/21c89811f58f/biochemj00344-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/591ea7d13631/biochemj00344-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/b7a81d524aa0/biochemj00344-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/dc6044d76bdc/biochemj00344-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/299013ee124f/biochemj00344-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/1152252/21c89811f58f/biochemj00344-0062-b.jpg

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1
Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.单核细胞和血小板共享糖蛋白IIb和IIIa，而在I型Glanzmann血小板无力症中，这两种细胞均缺乏这些糖蛋白。
Biochem J. 1983 Aug 15;214(2):331-7. doi: 10.1042/bj2140331.
2
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5
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6
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No relationship in the expression of Mo-1 on monocytes and GP IIb-IIIa on platelets in Glanzmann's thrombasthenia.在Glanzmann血小板无力症中，单核细胞上的Mo-1表达与血小板上的糖蛋白IIb-IIIa表达之间无相关性。
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Glycoproteins of platelet membranes from Glanzmann's thrombasthenia. A comparison with normal using carbohydrate-specific or protein-specific labelling techniques and high-resolution two-dimensional gel electrophoresis.血小板无力症患者血小板膜糖蛋白。采用碳水化合物特异性或蛋白质特异性标记技术及高分辨率二维凝胶电泳与正常人进行比较。
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Studies on platelet glycoproteins in Glanzmann's thrombasthenia using 125I-labelled lectins.使用¹²⁵I标记凝集素对血小板无力症患者血小板糖蛋白的研究。
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3
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本文引用的文献

1
Participation of ADP in the binding of fibrinogen to thrombin-stimulated platelets.二磷酸腺苷参与纤维蛋白原与凝血酶刺激的血小板的结合。
Blood. 1980 Sep;56(3):553-5.
2
Immunochemical evidence for protein abnormalities in platelets from patients with Glanzmann's thrombasthenia and Bernard-Soulier syndrome.血小板无力症和巨大血小板综合征患者血小板中蛋白质异常的免疫化学证据。
J Clin Invest. 1980 Mar;65(3):722-31. doi: 10.1172/JCI109719.
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Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation.
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Absence of platelet membrane glycoproteins IIb/IIIa from monocytes.单核细胞中缺乏血小板膜糖蛋白IIb/IIIa。
J Exp Med. 1985 May 1;161(5):972-83. doi: 10.1084/jem.161.5.972.
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A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells.一种针对人血小板糖蛋白IIIa的单克隆抗体在培养的人内皮细胞中检测到一种相关蛋白。
J Clin Invest. 1985 Mar;75(3):896-901. doi: 10.1172/JCI111789.
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Aggregation of human peripheral blood mononuclear cells by calcium ionophore A23187. Comparison with the aggregation of platelets and defective response in Glanzmann's thrombasthenia.钙离子载体A23187诱导人外周血单个核细胞聚集。与血小板聚集及Glanzmann血小板无力症中的缺陷反应比较。
Agents Actions. 1988 Jun;24(1-2):165-71. doi: 10.1007/BF01968096.
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Synthesis of analogs of human platelet membrane glycoprotein IIb-IIIa complex by chicken peripheral blood thrombocytes.鸡外周血血小板生成人血小板膜糖蛋白IIb-IIIa复合物类似物的合成
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7319-23. doi: 10.1073/pnas.82.21.7319.
8
Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells.血小板膜糖蛋白GPIIb/IIIa与多种细胞表达的细胞表面分子之间的免疫关系。
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6002-6. doi: 10.1073/pnas.83.16.6002.
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Expression of CD4 by human megakaryocytes.人类巨核细胞中CD4的表达。
Proc Natl Acad Sci U S A. 1990 Oct;87(20):8085-9. doi: 10.1073/pnas.87.20.8085.
10
Fc epsilon receptor II-positive macrophages and platelets: potent effector cells in allergy and defence against helminth parasites.Fcε受体II阳性巨噬细胞和血小板：过敏及抗蠕虫寄生虫防御中的强效效应细胞
Springer Semin Immunopathol. 1990;12(4):349-63. doi: 10.1007/BF00225323.
纤维蛋白原与其血小板受体的相互作用，作为ADP诱导血小板聚集多步反应的一部分。
J Biol Chem. 1980 Jan 10;255(1):154-61.
4
A method for the isolation of alpha-granules from human platelets.一种从人血小板中分离α-颗粒的方法。
Thromb Res. 1980;20(5-6):669-81. doi: 10.1016/0049-3848(80)90155-3.
5
Evidence for release of soluble, but not of membrane-integrated, proteins from human platelet alpha-granules.关于人血小板α-颗粒释放可溶性而非膜整合蛋白的证据。
Biochim Biophys Acta. 1982 Mar 18;702(1):81-9. doi: 10.1016/0167-4838(82)90029-2.
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In vitro differentiation of human monocytes. Differences in monocyte phenotypes induced by cultivation on glass or on collagen.人单核细胞的体外分化。在玻璃或胶原蛋白上培养诱导的单核细胞表型差异。
J Exp Med. 1982 Oct 1;156(4):1101-14. doi: 10.1084/jem.156.4.1101.
7
Thromboplastin (factor III) activity in human monocytes induced by immune complexes.免疫复合物诱导的人单核细胞中凝血活酶（因子III）活性
Eur J Clin Invest. 1982 Jun;12(3):229-34. doi: 10.1111/j.1365-2362.1982.tb00997.x.
8
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Blood. 1982 Sep;60(3):767-71.
9
Crossed immunoelectrophoresis of human platelet membranes. The major antigen consists of a complex of glycoproteins, GPIIb and GPIIIa, held together by Ca2+ and missing in Glanzmann's thrombasthenia.人血小板膜的交叉免疫电泳。主要抗原由糖蛋白GPIIb和GPIIIa的复合物组成，该复合物由Ca2+维系在一起，在Glanzmann血小板无力症中缺失。
J Biol Chem. 1982 Jul 25;257(14):8331-6.
10
Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen.血小板膜糖蛋白IIb和IIIa与纤维蛋白原的复合物形成。
J Clin Invest. 1982 Feb;69(2):263-9. doi: 10.1172/jci110448.