Whitmore W F, Prout G R
J Urol. 1982 May;127(5):902-5. doi: 10.1016/s0022-5347(17)54123-3.
Eight patients who received high dose external beam radiation therapy for low stage (O and A) bladder cancer with curative intent subsequently presented with recurrent tumors or complications of radiotherapy that led to cystectomy. The dismal results of high dose radiotherapy in these patients prompted us to review the published results for so-called definitive radiation therapy in patients with low stage bladder cancer. From this review and our own patients we conclude that high dose external beam radiotherapy is less than optimal treatment for patients with low stage bladder cancer. This is true even for the subset of patients with tumor characteristics that place them at high risk for the subsequent development of invasive disease.
8例因低分期（O期和A期）膀胱癌接受大剂量外照射放疗以期治愈的患者，随后出现了复发性肿瘤或放疗并发症，最终导致膀胱切除术。这些患者大剂量放疗的糟糕结果促使我们回顾已发表的关于低分期膀胱癌所谓根治性放疗的结果。通过此次回顾以及我们自己的患者情况，我们得出结论：大剂量外照射放疗并非低分期膀胱癌患者的最佳治疗方法。即使对于那些具有肿瘤特征、后续发生浸润性疾病风险较高的患者亚组也是如此。
