Fried G, Nestler E J, De Camilli P, Stjärne L, Olson L, Lundberg J M, Hökfelt T, Ouimet C C, Greengard P
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2717-21. doi: 10.1073/pnas.79.8.2717.
The cellular and subcellular distribution of protein I, a major brain phosphoprotein, has been studied in the peripheral nervous system. The levels of protein I in various peripheral nerves and innervated peripheral tissues were determined by radioimmunoassay and radioimmunolabeling of polyacrylamide gels. The results indicated tha protein I is present throughout the peripheral nervous system. Denervation studies of adrenal medulla and iris suggested that the protein I contained in peripheral tissues is localized to the neuronal elements innervating those tissues. Protein I was found to be enriched in neurotransmitter vesicle fractions of peripheral nervous tissue. Moreover, protein I appeared to be transported from cell bodies to axons terminals at least partly in association with neurotransmitter vesicles.
