Rihmer Z, Arató M, Szentistványi I, Bánki C M
Psychiatry Res. 1982 Apr;6(2):197-201. doi: 10.1016/0165-1781(82)90007-5.
The red blood cell/plasma concentration ratio (LR) was studied in 45 female patients with bipolar affective illness who responded to prophylactic lithium treatment. Patients were subdivided according to bipolar I vs. bipolar II diagnosis and presence vs. absence of a family history of affective illness. Mean LRs were significantly higher in bipolar II patients and in those with a positive family history of affective illness, but there was no relationship between diagnosis and family history. Results indicate that LR is genetically controlled and may be a biological marker distinguishing bipolar I and bipolar II patients, and also patients with positive or negative family history of affective illness.
对45名接受预防性锂治疗有反应的双相情感障碍女性患者的红细胞/血浆浓度比（LR）进行了研究。患者根据双相I型与双相II型诊断以及有无情感障碍家族史进行细分。双相II型患者以及有情感障碍家族史阳性的患者的平均LR显著更高，但诊断与家族史之间没有关联。结果表明，LR受基因控制，可能是区分双相I型和双相II型患者以及有情感障碍家族史阳性或阴性患者的生物学标志物。
