Maj M, Del Vecchio M, Starace F, Pirozzi R, Kemali D
Acta Psychiatr Scand. 1984 Jan;69(1):37-44. doi: 10.1111/j.1600-0447.1984.tb04514.x.
A set of socio-demographic, clinical, psychological and biological variables was examined in 100 patients diagnosed according to Perris as bipolar affective psychotics or unipolar depressive psychotics, maintained on prophylactic lithium for 2 years and divided into responders and non-responders to this treatment on the basis of strict criteria. The results confirmed the potential role of four indices as predictors of response to prophylaxis: a positive family history of bipolar affective illness and a high red blood cell/plasma lithium ratio (positive predictors) and the presence of the HLA-A3 antigen and a high score on the Neuroticism Scale of the Eysenck Personality Questionnaire (negative predictors). A stepwise discriminant analysis showed that neuroticism score, lithium ratio and HLA-A3 antigen, taken together, correctly classified 74.6% of responders and 68.3% of non-responders. It is hypothesized that these variables as a group may be of practical value in predicting response to lithium prophylaxis, and that pharmacogenetic and, perhaps, personality factors may be involved in treatment failures.
对100名根据佩里斯标准诊断为双相情感性精神病或单相抑郁性精神病的患者进行了一组社会人口统计学、临床、心理和生物学变量的检查。这些患者接受了为期2年的预防性锂治疗，并根据严格标准分为该治疗的反应者和无反应者。结果证实了四个指标作为预防反应预测因子的潜在作用：双相情感性疾病的阳性家族史和高红细胞/血浆锂比值（阳性预测因子）以及HLA - A3抗原的存在和艾森克人格问卷神经质量表的高分（阴性预测因子）。逐步判别分析表明，神经质得分、锂比值和HLA - A3抗原综合起来正确分类了74.6%的反应者和68.3%的无反应者。据推测，这些变量作为一个整体可能在预测锂预防反应方面具有实际价值，并且药物遗传学以及可能的人格因素可能与治疗失败有关。
