Kocsis J H, Kantor J S, Lieberman K W, Stokes P E
J Affect Disord. 1982 Sep;4(3):213-8. doi: 10.1016/0165-0327(82)90005-2.
Erythrocyte/plasma lithium ratios were determined in 41 polar manic depressive outpatients maintained on lithium for a mean of 64 months. Sixteen patients experienced affective episodes requiring additional pharmacologic intervention during periods when their plasma lithium averaged 0.7 meq/l or above for at least 3 preceding months and they were on no concurrent medication known to induce depression or mania. These patients considered to be a homogeneous group of non-responders to lithium, had a mean lithium ratio of 0.50 (range 0.15-1.16). Seven patients experienced affective symptoms at plasma levels below 0.7 meq/1 and/or while taking concurrent medication known to induce affective symptoms, and therefore could not be categorized clinically as lithium non-responders or responders. Eighteen remaining patients, who had no affective episodes during lithium maintenance, were found to have a mean erythrocyte/plasma ratio of 0.52 (range 0.19-1.05). This latter group of apparent responders should be considered heterogeneous in that it may include spontaneous remitters. The difference in mean ratios between the non-responder group and the apparent responder group was not statistically significant. These findings support the contention that the erythrocyte/plasma lithium ratio does not correlate with response of bipolar outpatients to maintenance lithium.
对41名维持锂盐治疗平均64个月的极地躁狂抑郁症门诊患者测定了红细胞/血浆锂比值。16名患者在之前至少3个月血浆锂平均水平为0.7meq/l或更高且未同时服用已知可诱发抑郁或躁狂的药物期间经历了情感发作，需要额外的药物干预。这些被认为是对锂盐无反应的同质患者组，其平均锂比值为0.50（范围0.15 - 1.16）。7名患者在血浆水平低于0.7meq/1和/或同时服用已知可诱发情感症状的药物时出现情感症状，因此在临床上不能归类为锂盐无反应者或反应者。其余18名在锂盐维持治疗期间没有情感发作的患者，其平均红细胞/血浆比值为0.52（范围0.19 - 1.05）。后一组明显有反应者应被视为异质的，因为它可能包括自发缓解者。无反应者组和明显有反应者组的平均比值差异无统计学意义。这些发现支持了红细胞/血浆锂比值与双相情感障碍门诊患者对维持性锂盐治疗的反应无关这一论点。
