多氯联苯的代谢与代谢产物
Metabolism and metabolites of polychlorinated biphenyls.
作者信息
Grimm Fabian A, Hu Dingfei, Kania-Korwel Izabela, Lehmler Hans-Joachim, Ludewig Gabriele, Hornbuckle Keri C, Duffel Michael W, Bergman Åke, Robertson Larry W
机构信息
Department of Pharmaceutical Sciences & Experimental Therapeutics, University of Iowa , Iowa City, IA , USA.
出版信息
Crit Rev Toxicol. 2015 Mar;45(3):245-72. doi: 10.3109/10408444.2014.999365. Epub 2015 Jan 28.
Abstract
Abstract The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.
摘要
摘要 多氯联苯（PCBs）的代谢过程复杂，会对毒性产生影响，进而影响对多氯联苯风险的评估。一般来说，在生物群尤其是人类的生物转化过程中会形成大量活性和稳定的代谢产物。本文的目的是概述多氯联苯的代谢情况，确定相关代谢产物及其存在情况。重点是多氯联苯在哺乳动物体内的代谢及其羟基、甲基磺酰基和硫酸化代谢产物，特别是那些在人体血液中持续存在的代谢产物。还讨论了潜在的细胞内靶点和健康风险。
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