van Weering H K, Wladimiroff J W
Acta Obstet Gynecol Scand. 1982;61(1):69-74. doi: 10.3109/00016348209156955.
Fifteen normal pregnant subjects inhaled a 7% CO2 mixture over a period of 5 min, resulting in a markedly increased rate of fetal breathing. In a further 15 normal pregnant subjects, an 80% O2 mixture was administered over a period of 10 min; during the second half of this stimulation period a significant increase in fetal breathing rate was noted. Finally, a 7% CO2 mixture was administered during a 5-min period to a total of 26 pregnant patients with fetal growth retardation. Seventeen of these 26 patients were subsequently administered an 80% O2 mixture during a 10-min period, immediately followed by a mixture of 80% O2 and 7% CO2 over a 5-min period. During both maternal hypercapnia and hyperoxia a marked increase in fetal breathing rate was noted, which was not essentially different from that seen in normal pregnancy. Administration of a mixture of O2 and CO2 did not result in any significant change in fetal breathing activity. At birth, all growth-retarded infants had an Apgar score of 6 or more at one minute. It can be concluded that respiration in both the normal and the clinically non-hypoxic growth-retarded fetus shows a similar reaction pattern towards alterations in maternal gaseous exchange.
15名正常孕妇吸入7%的二氧化碳混合气体5分钟，结果胎儿呼吸频率显著增加。在另外15名正常孕妇中，给予80%的氧气混合气体10分钟；在该刺激期的后半段，观察到胎儿呼吸频率显著增加。最后，在5分钟内给予26名胎儿生长受限的孕妇7%的二氧化碳混合气体。这26名患者中有17名随后在10分钟内给予80%的氧气混合气体，紧接着在5分钟内给予80%氧气和7%二氧化碳的混合气体。在母体高碳酸血症和高氧血症期间，均观察到胎儿呼吸频率显著增加，这与正常妊娠时观察到的情况没有本质区别。给予氧气和二氧化碳的混合气体并未导致胎儿呼吸活动出现任何显著变化。出生时，所有生长受限的婴儿1分钟时的阿氏评分均为6分或更高。可以得出结论，正常和临床上无缺氧的生长受限胎儿的呼吸对母体气体交换变化表现出相似的反应模式。
