Gagnon R, Hunse C, Vijan S
Department of Obstetrics and Gynecology, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Canada.
Am J Obstet Gynecol. 1990 Dec;163(6 Pt 1):1894-9. doi: 10.1016/0002-9378(90)90770-8.
Thirteen pregnant women who subsequently were delivered of infants with birth weights less than the 3rd percentile were studied for examination of fetal heart rate and fetal activity patients during maternal administration of oxygen at a concentration of 50% or room air for 2 hours. None of the fetuses was acidotic at birth. Maternal transcutaneous PO2 levels increased from 79 +/- 3 mm Hg to 158 +/- 10 mm Hg for the 2 hours of observation. The results indicated that maternal hyperoxia produced sustained fetal breathing activity that was almost 100% higher than that in room air (analysis of variance, p = 0.024). Gross fetal body movements, fetal heart rate accelerations, and fetal heart rate variability increased significantly with increasing observation time (analysis of variance, p less than 0.01), but were not significantly altered by maternal hyperoxia or room air. We conclude that despite significant change in fetal breathing activity, ultrasonographic observation of fetal behavioral activity during maternal hyperoxia could not be used to differentiate severely growth-retarded from normally grown human fetuses. We speculate that altered fetal heart rate and fetal body movement patterns usually associated with intrauterine growth retardation might be related to altered development of the fetal central nervous system and are not reversible during prolonged maternal administration of oxygen.
对13名随后分娩出出生体重低于第3百分位数婴儿的孕妇进行了研究，在孕妇吸入浓度为50%的氧气或室内空气2小时期间，检测胎儿心率和胎儿活动情况。出生时没有一个胎儿出现酸中毒。在2小时的观察期内，孕妇经皮氧分压水平从79±3毫米汞柱升至158±10毫米汞柱。结果表明，孕妇高氧血症会引起持续的胎儿呼吸活动，其比吸入室内空气时高出近100%（方差分析，p = 0.024）。随着观察时间的增加，胎儿总体躯体运动、胎儿心率加速和胎儿心率变异性显著增加（方差分析，p＜0.01），但孕妇高氧血症或室内空气对此并无显著影响。我们得出结论，尽管胎儿呼吸活动有显著变化，但在孕妇高氧血症期间对胎儿行为活动进行超声观察，无法用于区分严重生长受限胎儿与正常生长的人类胎儿。我们推测，通常与宫内生长受限相关的胎儿心率和胎儿躯体运动模式改变，可能与胎儿中枢神经系统发育改变有关，且在孕妇长时间吸氧期间不可逆转。
