Ritter M A, Gioe T J
Clin Orthop Relat Res. 1982 Jul(167):113-7.
Three patients exhibiting Grade III para-articular ectopic ossification following bilateral hip arthroplasty were successfully treated by excision of the bone and small-dose, short-term indomethacin therapy. Based on these results, a preliminary study was performed to determine the effect of indomethacin used prophylactically in patients who were predisposed to ectopic ossification and were undergoing total hip arthroplasty. Of a retrospective control group of 24 hips with extensive bilateral osteoarthritis, 63% were found to develop ectopic ossification following arthroplasty compared to 17% of a similar group treated with indomethacin (p less than 0.001). The ectopic ossification in the indomethacin-treated group possibly was of lesser severity (Grade I) than that encountered in the control group.
三名双侧髋关节置换术后出现Ⅲ级关节周围异位骨化的患者通过切除骨组织及小剂量短期吲哚美辛治疗获得成功。基于这些结果，开展了一项初步研究，以确定吲哚美辛预防性用于易发生异位骨化且正在接受全髋关节置换术患者的效果。在一个回顾性对照组中，24例患有广泛性双侧骨关节炎的髋关节，63%在置换术后出现异位骨化，相比之下，在接受吲哚美辛治疗的类似组中这一比例为17%（p<0.001）。吲哚美辛治疗组的异位骨化严重程度可能低于对照组（Ⅰ级）。
