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抗坏血酸和二甲基亚砜对柔红霉素和阿霉素生物活性的增强作用。

Potentiation of the biological activities of daunomycin and adriamycin by ascorbic acid and dimethylsulfoxide.

作者信息

Marián M, Matkovics B

出版信息

Experientia. 1982 May 15;38(5):573-4. doi: 10.1007/BF02327056.

DOI:10.1007/BF02327056
PMID:6807712
Abstract

L-Ascorbic acid (0.57 mM) and dimethylsulfoxide (14.1 mM) were found to potentiate four times the antibacterial activities of daunomycin and adriamycin in the Staphylococcus aureus test. This effect, however, could not be demonstrated against eukaryotic cells and leukemia P 388 in mice.

摘要

在金黄色葡萄球菌试验中，发现L-抗坏血酸（0.57毫摩尔）和二甲基亚砜（14.1毫摩尔）可使柔红霉素和阿霉素的抗菌活性增强四倍。然而，在小鼠体内针对真核细胞和白血病P 388无法证明这种效果。

相似文献

1
Potentiation of the biological activities of daunomycin and adriamycin by ascorbic acid and dimethylsulfoxide.抗坏血酸和二甲基亚砜对柔红霉素和阿霉素生物活性的增强作用。
Experientia. 1982 May 15;38(5):573-4. doi: 10.1007/BF02327056.
2
Antimitochondrial activity of adriamycin and daunomycin on Saccharomyces cerevisiae.
Pharmacol Res Commun. 1977 Feb;9(2):155-64. doi: 10.1016/s0031-6989(77)80018-0.
3
Role of host defense merchanisms in the antitumor activity of adriamycin and daunomycin in mice.宿主防御机制在阿霉素和柔红霉素对小鼠的抗肿瘤活性中的作用。
J Natl Cancer Inst. 1979 Jul;63(1):61-6.
4
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.新型蒽环类抗生素阿克拉霉素-A及其类似物的抗肿瘤活性与毒性
Gan. 1977 Oct;68(5):685-90.
5
Resistance and cross-resistance of cultured leukemia P388 cells to vincristine, adriamycin, adriamycin analogs, and actinomycin D.培养的白血病P388细胞对长春新碱、阿霉素、阿霉素类似物及放线菌素D的耐药性和交叉耐药性
J Natl Cancer Inst. 1978 Dec;61(6):1521-4.
6
Antineoplastic activity and pharmacokinetics of adriamycin and daunomycin in tumor bearing mice.阿霉素和柔红霉素在荷瘤小鼠体内的抗肿瘤活性及药代动力学
Oncology. 1977;34(4):173-8. doi: 10.1159/000225216.
7
[Experimental studies on the cytotoxic effects of adriamycin and daunomycin used alone and in combination (author's transl)].
Haematologica. 1978 Apr;63(2):182-208.
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Effects of daunomycin and adriamycin on the murine sarcoma virus (Moloney) in vitro.柔红霉素和阿霉素对小鼠肉瘤病毒（莫洛尼氏）的体外作用。
Rev Eur Etud Clin Biol. 1972 Jun-Jul;17(6):622-5.
9
Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.钙调蛋白抑制剂三氟拉嗪对柔红霉素和阿霉素（阿德里亚霉素）诱导多柔比星耐药的P388小鼠白血病细胞发生细胞周期进程紊乱及细胞毒性作用中的诱导和表达作用。
Br J Cancer. 1986 Apr;53(4):561-6. doi: 10.1038/bjc.1986.88.
10
Comparative effect of daunomycin and adriamycin on nucleic acid metabolism in leukemic cells in vitro.柔红霉素与阿霉素对体外白血病细胞核酸代谢的比较作用
Gan. 1974 Jun;65(3):237-47.

本文引用的文献

1
On the origin of the toxicity of toxoflavin.关于毒黄素毒性的起源
Biochim Biophys Acta. 1961 Sep 30;52:502-8. doi: 10.1016/0006-3002(61)90408-5.
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Combination chemoprevention of cancer.
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Binding specificity of chemically and enzymatically activated anthracycline anticancer agents to nucleic acids.化学和酶促活化蒽环类抗癌药物与核酸的结合特异性。
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4
Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin.小鼠心脏针对活性氧代谢产物的酶防御机制：阿霉素引起的改变
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5
Resistance to adriamycin cytotoxicity among respiratory-deficient mutants in yeast.酵母呼吸缺陷型突变体对阿霉素细胞毒性的抗性。
Antimicrob Agents Chemother. 1980 Mar;17(3):443-9. doi: 10.1128/AAC.17.3.443.
6
The interaction of hydroxyl radicals with dimethylsulfoxide produces formaldehyde.羟基自由基与二甲基亚砜相互作用会产生甲醛。
FEBS Lett. 1980 Jul 28;116(2):220-2. doi: 10.1016/0014-5793(80)80648-x.
7
Quinine: effect on Tetrahymena pyriformis. I. Inhibition of synchronized cell division and site of action.奎宁：对梨形四膜虫的作用。I. 对同步细胞分裂的抑制及作用位点。
Pharmacology. 1969;2(4):247-56. doi: 10.1159/000136026.
8
Lethal action and metabolic effects of streptonigrin on Escherichia coli.链黑菌素对大肠杆菌的致死作用及代谢影响
Mol Pharmacol. 1968 Nov;4(6):549-65.
9
Reducing compounds in radioprotection and radiosensitization: model experiments using ascorbic acid.
Int J Radiat Biol Relat Stud Phys Chem Med. 1973 Jan;23(1):51-65. doi: 10.1080/09553007314550051.
10
The oxidation of ascorbate by electron affinic drugs and carcinogens.电子亲和性药物和致癌物对抗坏血酸盐的氧化作用。
Photochem Photobiol. 1978 Oct-Nov;28(4-5):869-76. doi: 10.1111/j.1751-1097.1978.tb07034.x.