抗坏血酸和二甲基亚砜对柔红霉素和阿霉素生物活性的增强作用。
Potentiation of the biological activities of daunomycin and adriamycin by ascorbic acid and dimethylsulfoxide.
作者信息
Marián M, Matkovics B
出版信息
Experientia. 1982 May 15;38(5):573-4. doi: 10.1007/BF02327056.
PMID:6807712
Abstract
L-Ascorbic acid (0.57 mM) and dimethylsulfoxide (14.1 mM) were found to potentiate four times the antibacterial activities of daunomycin and adriamycin in the Staphylococcus aureus test. This effect, however, could not be demonstrated against eukaryotic cells and leukemia P 388 in mice.
摘要
在金黄色葡萄球菌试验中，发现L-抗坏血酸（0.57毫摩尔）和二甲基亚砜（14.1毫摩尔）可使柔红霉素和阿霉素的抗菌活性增强四倍。然而，在小鼠体内针对真核细胞和白血病P 388无法证明这种效果。
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