Wilkoff L J, Dulmadge E A
J Natl Cancer Inst. 1978 Dec;61(6):1521-4.
Cultured P388 cells derived from leukemia P388 passaged in vivo in (C57BL X DBA/2)F1 mice were approximately one-tenth less sensitive to N-trifluoroacetyladriamycin-14-valerate (AD32) and cinerubin A, inasmuch as the concentrations of these agents had to be increased tenfold to produce a reduction in cell viability of the same order of magnitude as that produced by adriamycin, daunomycin, or actinomycin D. Cultured P388 cells derived from resistant cell populations developed in vivo retained their resistance to vincristine. These resistant cells exhibited cross-resistance to actinomycin D, adriamycin, daunomycin, and AD32, but cross-resistance to cinerubin A could not be detected. Data also showed that the vincristine-resistant cells were more sensitive to AD32 (2.8 x 10(-6) M) than to adriamycin (3.4 x 10(-6) M) during a 6-hour exposure of cells to agents.
在（C57BL×DBA/2）F1小鼠体内传代培养的白血病P388来源的P388细胞，对N-三氟乙酰阿霉素-14-戊酸酯（AD32）和烬灰红菌素A的敏感性约低十分之一，因为这些药物的浓度必须增加10倍才能产生与阿霉素、柔红霉素或放线菌素D相同数量级的细胞活力降低。从体内产生的耐药细胞群体中获得的培养P388细胞对长春新碱仍保持耐药性。这些耐药细胞对放线菌素D、阿霉素、柔红霉素和AD32表现出交叉耐药性，但未检测到对烬灰红菌素A的交叉耐药性。数据还表明，在细胞暴露于药物6小时期间，长春新碱耐药细胞对AD32（2.8×10^(-6) M）比对阿霉素（3.4×10^(-6) M）更敏感。
