Weir D M, Stewart J, Glass E
Immunobiology. 1982 Apr;161(3-4):334-44. doi: 10.1016/S0171-2985(82)80090-9.
A "lectin-like" receptor for bacterial cell wall sugars, originally described in the membrane of mouse peritoneal macrophages, which facilitates binding of various bacteria to the macrophage surface, has now been shown to be present on most phagocytes from a variety of species. The role of such a receptor in the inflammatory response has been investigated by examining changes in its expression in response to chemoattractants. The chemoattractants, whilst enhancing or not altering expression of C3 and Fc receptors, respectively, appeared to decrease lectin receptor expression. The possibility of a relationship between I-region gene products of the major histocompatibility complex (MHC) and the bacterial binding lectin receptor was investigated. It was found that various conventional and monoclonal antibodies directed against I-region determinants inhibited binding of bacteria to mouse peritoneal macrophages. These findings suggest the need to examine the possibility that, in addition to phagocytosis and elimination of bacteria, the lectin receptor may also be involved in antigen presentation and macrophage-T-lymphocyte cooperative events leading to an immune response.
一种最初在小鼠腹腔巨噬细胞膜中发现的、针对细菌细胞壁糖类的“类凝集素”受体，它能促进各种细菌与巨噬细胞表面的结合，现在已证明存在于多种物种的大多数吞噬细胞上。通过检测其在趋化因子作用下的表达变化，研究了这种受体在炎症反应中的作用。这些趋化因子分别增强或不改变C3和Fc受体的表达，但似乎会降低凝集素受体的表达。研究了主要组织相容性复合体（MHC）的I区基因产物与细菌结合凝集素受体之间存在关联的可能性。结果发现，各种针对I区决定簇的传统抗体和单克隆抗体均可抑制细菌与小鼠腹腔巨噬细胞的结合。这些发现表明，除了吞噬和清除细菌外，凝集素受体可能还参与抗原呈递以及导致免疫反应的巨噬细胞与T淋巴细胞协同事件，有必要对此可能性进行研究。
