Glass E J, Stewart J, Weir D M
Immunology. 1983 Sep;50(1):165-73.
The expression of various receptors and other surface determinants on resident, glycogen-and Corynebacterium parvum- elicited mouse peritoneal macrophages has been described. Macrophage Fc (IgG2b) receptors and I-A antigens were slightly increased after stimulation and a more marked increase was shown after activation with C. parvum. Complement receptor expression was enhanced after stimulation but was markedly reduced after activation. C. parvum-elicited macrophages, and to a lesser extent glycogen-elicited macrophages, showed a reduction in lectin-like receptors which recognize bacterial cell-wall sugars. Surface mannosyl determinants of the macrophage membrane were apparently increased after activation. The environment thus can be seen to influence the expression of macrophage surface receptors and antigens. These alterations are likely to influence the role of the macrophage in the immune response.
已对驻留的、糖原诱导的和短小棒状杆菌诱导的小鼠腹腔巨噬细胞上各种受体及其他表面决定簇的表达进行了描述。巨噬细胞Fc（IgG2b）受体和I-A抗原在刺激后略有增加，在用短小棒状杆菌激活后增加更为明显。补体受体表达在刺激后增强，但在激活后显著降低。短小棒状杆菌诱导的巨噬细胞，以及程度较轻的糖原诱导的巨噬细胞，识别细菌细胞壁糖的凝集素样受体减少。激活后巨噬细胞膜的表面甘露糖基决定簇明显增加。因此可以看出环境会影响巨噬细胞表面受体和抗原的表达。这些改变可能会影响巨噬细胞在免疫反应中的作用。
