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在小鼠对绵羊红细胞的应答中，假定的次要组织相容性基因而非免疫球蛋白重链（IgH）基因的差异可阻止T细胞致敏及T-B细胞合作。

Differences in putative minor histocompatibility but not IgH genes can prevent T-cell priming and T--B co-operation in the response of mice to sheep erythrocytes.

作者信息

Dresser D W, Popham A M, Hunt R

出版信息

Immunology. 1982 Jul;46(3):643-51.

PMID:6807840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555315/
Abstract

A positive association has been observed in Igh allotype "congenic' mice between skin graft rejection and a block to effective T--B co-operation in the development of both IgM and IgG responses to sheep erythrocytes. Mismatch of Igh alone is insufficient for such a block to become apparent since pairs of Igh-allotype congenic strains of mice which reciprocally accept skin grafts for at least 5 weeks, show successful positive co-operation (help) between T and B cells. The observed block is manifest both during the education (priming) of T cells in irradiated (first stage) recipients and during co-operation between primed T cells and unprimed B cells in second stage irradiated "syngeneic' recipients.

摘要

在Igh同种异型“同源”小鼠中，已观察到皮肤移植排斥与在针对绵羊红细胞的IgM和IgG反应发育过程中有效T - B细胞合作受阻之间存在正相关。仅Igh不匹配不足以使这种阻碍明显显现，因为相互接受皮肤移植至少5周的Igh同种异型同源小鼠品系对，显示出T细胞和B细胞之间成功的正向合作（辅助）。观察到的阻碍在受辐照（第一阶段）受体中T细胞的致敏（启动）过程以及在第二阶段受辐照的“同基因”受体中致敏T细胞与未致敏B细胞之间的合作过程中均有体现。

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Differences in putative minor histocompatibility but not IgH genes can prevent T-cell priming and T--B co-operation in the response of mice to sheep erythrocytes.在小鼠对绵羊红细胞的应答中，假定的次要组织相容性基因而非免疫球蛋白重链（IgH）基因的差异可阻止T细胞致敏及T-B细胞合作。
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本文引用的文献

1
A mature T lymphocyte marker closely linked to Igh-1 that is expressed on the precursor for the suppressor T cell regulating a primary response to SRBC.一种与Igh-1紧密相连的成熟T淋巴细胞标志物，在调节对SRBC初次反应的抑制性T细胞前体上表达。
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A family of T-cell alloantigens linked to Igh-1.与Igh-1相关的T细胞同种异体抗原家族。
Nature. 1981 Oct 29;293(5835):742-5. doi: 10.1038/293742a0.
3
Priming of T helper cells by antigen-activated B cells. B cell-primed Lyt-1+ helper cells are restricted to cooperate with B cells expressing the IgvH phenotype of the priming B cells.抗原激活的B细胞对辅助性T细胞的致敏作用。经B细胞致敏的Lyt-1⁺辅助性细胞只能与表达致敏B细胞IgvH表型的B细胞协同作用。
J Exp Med. 1981 May 1;153(5):1236-45. doi: 10.1084/jem.153.5.1236.
4
Influence of Igh-linked gene products on the generation of T helper cells in the response to sheep erythrocytes.Igh 连锁基因产物对绵羊红细胞应答中辅助性 T 细胞生成的影响。
J Exp Med. 1981 May 1;153(5):1225-35. doi: 10.1084/jem.153.5.1225.
5
T cell regulation of isotype expression. The requirement for a second Ig-specific helper T cell population for the induction of IgG responses.T细胞对抗体类型表达的调节。诱导IgG应答需要第二种Ig特异性辅助性T细胞群体。
Eur J Immunol. 1981 Sep;11(9):705-10. doi: 10.1002/eji.1830110907.
6
The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.抑制性T细胞同种异体抗原Tsud定位于免疫球蛋白同种异型基因附近，可能是T细胞受体上的重链恒定区标志物。
J Exp Med. 1981 Apr 1;153(4):801-10. doi: 10.1084/jem.153.4.801.
7
Preparation and properties of a cytotoxic monoclonal rat anti-mouse Thy-1 antibody.一种细胞毒性大鼠抗小鼠Thy-1单克隆抗体的制备及其特性
J Immunol Methods. 1982;49(1):17-23. doi: 10.1016/0022-1759(82)90362-3.
8
A test for histocompatibility between sublines of the CBA strain of mice.小鼠CBA品系亚系之间组织相容性的检测。
Transplantation. 1965 Nov;3(6):766-8.
9
Immunological activity of thymus and thoracic-duct lymphocytes.胸腺和胸导管淋巴细胞的免疫活性
Proc Natl Acad Sci U S A. 1968 Jan;59(1):296-303. doi: 10.1073/pnas.59.1.296.
10
Active suppression of immunoglobulin allotype synthesis. I. Chronic suppression after perinatal exposure to maternal antibody to paternal allotype in (SJL x BALB-c)F 1 mice.免疫球蛋白同种异型合成的主动抑制。I. 围产期暴露于母体抗父本同种异型抗体后，(SJL×BALB-c)F1小鼠的慢性抑制。
J Exp Med. 1972 May 1;135(5):1151-62. doi: 10.1084/jem.135.5.1151.

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