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1
The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.抑制性T细胞同种异体抗原Tsud定位于免疫球蛋白同种异型基因附近，可能是T细胞受体上的重链恒定区标志物。
J Exp Med. 1981 Apr 1;153(4):801-10. doi: 10.1084/jem.153.4.801.
2
Genes for the mouse T cell alloantigens Tpre, Tthy, Tind, and Tsu are closely linked near Igh on chromosome 12.小鼠T细胞同种异体抗原Tpre、Tthy、Tind和Tsu的基因在第12号染色体上靠近Igh的位置紧密连锁。
J Exp Med. 1984 Jan 1;159(1):313-7. doi: 10.1084/jem.159.1.313.
3
T suppressor cells activated by anti-Tsud serum are Igh-V-restricted.被抗津血清激活的抑制性T细胞受免疫球蛋白重链可变区（Igh-V）限制。
Eur J Immunol. 1982 Jan;12(1):94-7. doi: 10.1002/eji.1830120118.
4
Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus.抗原特异性抑制性和增强性T细胞因子上的两种不同的同种异型决定簇，它们由与免疫球蛋白重链基因座连锁的基因编码。
J Exp Med. 1982 Jan 1;155(1):126-39. doi: 10.1084/jem.155.1.126.
5
T cell allotypic determinants encoded by genes linked to the immunoglobulin heavy chain locus. I. Establishment of monoclonal antibodies against allotypic determinants.由与免疫球蛋白重链基因座连锁的基因编码的T细胞同种异型决定簇。I. 针对同种异型决定簇的单克隆抗体的建立。
J Immunol. 1983 Jun;130(6):2920-5.
6
Influence of the immunoglobulin heavy chain locus on expression of the VK1GAC light chain.免疫球蛋白重链基因座对VK1GAC轻链表达的影响。
J Immunol. 1984 Jul;133(1):465-70.
7
Idiotypes and allotypes on Ia-binding alloactivated Lyt-1+,2-,3- T cells are coded for by genes linked to the igh-1 allotype locus.与Ia结合的同种异体活化的Lyt-1⁺、2⁻、3⁻ T细胞上的独特型和同种异型由与igh-1同种异型基因座连锁的基因编码。
J Immunol. 1983 Mar;130(3):1426-31.
8
Genetic chasing of T helper cell idiotype and allotype genes.T辅助细胞独特型和同种异型基因的遗传追踪
Immunogenetics. 1982;16(3):229-41. doi: 10.1007/BF00343312.
9
Idiotype regulation: evidence for the involvement of Igh-C-restricted T cells in the M-460 idiotype suppressive pathway.独特型调节：Igh-C 限制性 T 细胞参与 M-460 独特型抑制途径的证据。
Eur J Immunol. 1982 Jan;12(1):24-30. doi: 10.1002/eji.1830120107.
10
Genetic control of murine IgD structural heterogeneity.小鼠IgD结构异质性的遗传控制。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4256-9. doi: 10.1073/pnas.77.7.4256.

引用本文的文献

1
Fusion of DNA region to murine immunoglobulin heavy chain locus corresponds to plasmacytoma-associated chromosome translocation.DNA区域与小鼠免疫球蛋白重链基因座的融合对应于浆细胞瘤相关的染色体易位。
EMBO J. 1983;2(2):213-6. doi: 10.1002/j.1460-2075.1983.tb01407.x.
2
A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment.一株T15独特型阳性的抑制性T杂交瘤不使用T15重链可变区基因片段。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6984-8. doi: 10.1073/pnas.79.22.6984.
3
Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.Tthyd，一种与Igh-1相关的新的胸腺细胞同种异体抗原。对T细胞抗原受体转换机制的启示。
J Exp Med. 1982 Jan 1;155(1):52-60. doi: 10.1084/jem.155.1.52.
4
DNA sequence associated with chromosome translocations in mouse plasmacytomas.与小鼠浆细胞瘤中染色体易位相关的DNA序列。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6622-6. doi: 10.1073/pnas.79.21.6622.
5
Genetic analysis of the non-H-2-linked Ir genes controlling the cytotoxic T-cell response to H-Y in H-2d mice.对控制H-2d小鼠中细胞毒性T细胞对H-Y反应的非H-2连锁Ir基因的遗传分析。
Immunogenetics. 1982;16(6):593-601. doi: 10.1007/BF00372028.
6
Differences in putative minor histocompatibility but not IgH genes can prevent T-cell priming and T--B co-operation in the response of mice to sheep erythrocytes.在小鼠对绵羊红细胞的应答中，假定的次要组织相容性基因而非免疫球蛋白重链（IgH）基因的差异可阻止T细胞致敏及T-B细胞合作。
Immunology. 1982 Jul;46(3):643-51.
7
Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.小鼠T细胞杂交瘤和T淋巴瘤中免疫球蛋白重链基因的重排与转录
Proc Natl Acad Sci U S A. 1982 May;79(9):3015-9. doi: 10.1073/pnas.79.9.3015.
8
The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.T细胞上主要组织相容性复合体限制的抗原受体。I. 用单克隆抗体进行分离。
J Exp Med. 1983 Apr 1;157(4):1149-69. doi: 10.1084/jem.157.4.1149.
9
Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.Tpre是一种在12号染色体IgT - C区域编码的新的同种异体抗原，在裸鼠的骨髓、胎儿T细胞杂交体和胎儿胸腺中表达。
J Exp Med. 1983 Feb 1;157(2):419-32. doi: 10.1084/jem.157.2.419.
10
Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse.水貂细胞病灶诱导和嗜异性env基因家族在小鼠中的染色体定位。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6298-302. doi: 10.1073/pnas.80.20.6298.

本文引用的文献

1
Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells.通过对小鼠浆细胞瘤细胞的研究揭示B淋巴细胞发育过程中免疫球蛋白重链基因的重排。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1422-6. doi: 10.1073/pnas.77.3.1422.
2
Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.对小鼠免疫球蛋白重链基因和血清前白蛋白基因的连锁分析确定了它们在12号染色体上的位置，该位置靠近12F1带中的T(5;12)31H断点。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):550-3. doi: 10.1073/pnas.77.1.550.
3
Antibody gene linkage studies in (NZB X C58) recombinant-inbred lines.（新西兰黑鼠×C58）重组近交系中的抗体基因连锁研究。
J Immunol. 1980 Feb;124(2):787-9.
4
Polyclonal activation of Ts cells with antiserum directed against an IGH-1 linked candidate for a T-cell receptor constant region marker.用针对与T细胞受体恒定区标记物相关的IGH-1的抗血清对Ts细胞进行多克隆激活。
J Supramol Struct. 1980;14(2):175-82. doi: 10.1002/jss.400140206.
5
Antibody formation by single cells from lymph nodes and efferent lymph of sheep.绵羊淋巴结和输出淋巴中单个细胞的抗体形成。
J Exp Med. 1966 Oct 1;124(4):701-14. doi: 10.1084/jem.124.4.701.
6
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
7
Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.C型RNA肿瘤病毒的宿主基因控制：小鼠白血病病毒群特异性抗原的遗传
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3190-4. doi: 10.1073/pnas.68.12.3190.
8
Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse.免疫球蛋白重链基因和血清前白蛋白基因在小鼠中是连锁的。
Nature. 1975 Aug 21;256(5519):644-6. doi: 10.1038/256644a0.
9
A mature T lymphocyte subpopulation marker closely linked to the Ig-1 allotype Ch locus.一种与Ig-1同种异型Ch基因座紧密相关的成熟T淋巴细胞亚群标志物。
Eur J Immunol. 1979 Dec;9(12):948-55. doi: 10.1002/eji.1830091208.
10
Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus.Lyb-7，一种由与IgCH基因座连锁的基因控制的新型B细胞同种抗原。
J Immunol. 1979 Jun;122(6):2279-85.

抑制性T细胞同种异体抗原Tsud定位于免疫球蛋白同种异型基因附近，可能是T细胞受体上的重链恒定区标志物。

The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.

作者信息

Owen F L, Riblet R, Taylor B A

出版信息

J Exp Med. 1981 Apr 1;153(4):801-10. doi: 10.1084/jem.153.4.801.

DOI:10.1084/jem.153.4.801
PMID:6454740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186124/
Abstract

The mouse T cell alloantigen, Tsud, is expressed on a minority of mature, Lyt-2+ cells, and its expression is controlled by a gene linked to the immunoglobulin heavy chain gene cluster, Igh. Tsud can be assayed by immunofluorescence staining with an antiserum made in BALB/c mice against C.AL-20 concanavalin A blasts. This antiserum can also be used to induced T suppressor cells in mice expressing Tsu(d). Both of these assays were used to type several panels of recombinant inbred strains and Igh recombinant strains to accurately map the Tsu(d) locus. The Tsu(d) gene is located very near the heavy chain constant-region genes, Igh-C, on the side toward the prealbumin gene, Pre-1. Tsu(d) is not among the heavy chain variable-region genes, Igh-V, and thus is not a variable-region framework allotype, subgroup determinant, or idiotype. The map position suggest that the Tsu(d) antigen is a constant region allotypic determinant on the as yet uncharacterized T cell receptor.

摘要

小鼠T细胞同种异体抗原Tsud在少数成熟的Lyt-2⁺细胞上表达，其表达受与免疫球蛋白重链基因簇Igh相连的一个基因控制。可用BALB/c小鼠针对C.AL-20伴刀豆球蛋白A母细胞制备的抗血清通过免疫荧光染色来检测Tsud。该抗血清也可用于在表达Tsu(d)的小鼠中诱导T抑制细胞。这两种检测方法都用于对几个重组近交系和Igh重组系进行分型，以精确绘制Tsu(d)基因座图谱。Tsu(d)基因位于重链恒定区基因Igh-C非常靠近前白蛋白基因Pre-1的一侧。Tsu(d)不在重链可变区基因Igh-V中，因此不是可变区构架同种异型、亚组决定簇或独特型。图谱位置表明Tsu(d)抗原是尚未鉴定的T细胞受体上的恒定区同种异型决定簇。