Hunneyball I M, Stewart G A, Stanworth D R
Immunology. 1978 Jun;34(6):1053-61.
D-penicillamine given orally to rabbits at a dose of 15 mg/kg body weight, administered daily for long periods commencing prior to and at the time of immunization, reduced the concentration of specific IgG antibodies directed against ovalbumin. This effect was not observed when treatment with the drug commenced after immunization and the onset of a mono-articular arthritis. The concentration of serum IgA rose abruptly after antigen was injected intra-articularly to induce the arthritis. This increase was not affected by treatment with D-penicillamine. The concentration of serum IgA decreased markedly during the chronic phase of the mono-articular arthritis, falling below the lower limit of the normal range. Treatment with D-penicillamine for at least 50 days restored the serum IgA concentration to the middle of the normal range. D-penicillamine treatment had no significant effect on the concentration of IgG, or IgM in serum either before or after the onset of mono-articular arthritis.
以15毫克/千克体重的剂量给兔子口服D-青霉胺，从免疫前及免疫时开始长期每日给药，可降低针对卵清蛋白的特异性IgG抗体浓度。当在免疫及单关节性关节炎发作后开始用该药治疗时，未观察到这种效应。关节腔内注射抗原诱导关节炎后，血清IgA浓度急剧上升。这种升高不受D-青霉胺治疗的影响。在单关节性关节炎的慢性期，血清IgA浓度显著下降，降至正常范围下限以下。用D-青霉胺治疗至少50天可使血清IgA浓度恢复至正常范围的中间值。D-青霉胺治疗对单关节性关节炎发作前后血清中IgG或IgM的浓度均无显著影响。
